| Title: | Association between prescribing and intoxication rates for selected psychotropic drugs : a longitudinal observational study |
|---|
| Authors: | ID Dobravc Verbič, Matej (Author)
ID Grabnar, Iztok (Author)
ID Brvar, Miran (Author) |
|---|
| Files: |  PDF - Presentation file, download (1,61 MB)
MD5: 4F4FBCEDB82511CE1B18D9CA3F2B752A
 URL - Source URL, visit https://www.mdpi.com/1424-8247/17/1/143
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Psychotropic prescription drugs are commonly involved in intoxication events. The study's aim was to determine a comparative risk for intoxication in relation to prescribing rates for individual drugs. This was a nationwide observational study in Slovenian adults between 2015 and 2021. Intoxication events with psychotropic drugs were collected from the National Register of intoxications. Dispensing data, expressed in defined daily doses, were provided by the Health Insurance Institute of Slovenia. Intoxication/prescribing ratio values were calculated. The correlation between trends in prescribing and intoxication rates was assessed using the Pearson correlation coefficient. In total, 2640 intoxication cases with psychotropic prescription drugs were registered. Anxiolytics and antipsychotics were the predominant groups. Midazolam, chlormethiazole, clonazepam, sulpiride, and quetiapine demonstrated the highest risk of intoxication, while all antidepressants had a risk several times lower. The best trend correlation was found for the prescribing period of 2 years before the intoxication events. An increase of 1,000,000 defined daily doses prescribed resulted in an increase of fifty intoxication events for antipsychotics, twenty events for antiepileptics, and five events for antidepressants. Intoxication/prescribing ratio calculation allowed for a quantitative comparison of the risk for intoxication in relation to the prescribing rates for psychotropic drugs, providing additional understanding of their toxicoepidemiology. |
|---|
| Keywords: | intoxication, psychotropic drugs, prescribing, correlation, risk assessment |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2024 |
|---|
| Number of pages: | str. 1-13 |
|---|
| Numbering: | Vol. 17, iss. 1, [article no.] 143 |
|---|
| PID: | 20.500.12556/DiRROS-30159  |
|---|
| UDC: | 615 |
|---|
| ISSN on article: | 1424-8247 |
|---|
| DOI: | 10.3390/ph17010143 |
|---|
| COBISS.SI-ID: | 184008707 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 5. 2. 2024;
|
|---|
| Publication date in DiRROS: | 16.06.2026 |
|---|
| Views: | 126 |
|---|
| Downloads: | 90 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
