| Title: | The outcome of metabolic and bariatric surgery in morbidly obese patients with different genetic variants associated with obesity : a systematic review |
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| Authors: | ID Zafirovska, Marija (Author)
ID Zafirovski, Aleksandar (Author)
ID Režen, Tadeja (Author)
ID Pintar, Tadeja (Author) |
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| Files: |  PDF - Presentation file, download (617,48 KB)
MD5: 5B16EA591E8CAB1057306AC60F9B2964
 URL - Source URL, visit https://www.mdpi.com/2072-6643/16/15/2510
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities, though individual responses vary. This systematic review examines how genetic variants influence MBS outcomes in morbidly obese patients. A comprehensive search in PubMed, Embase, Medline, and the Cochrane Library identified 1572 studies, with 52 meeting the inclusion criteria. Two reviewers independently filtered and selected studies, including relevant cross-references. Research focused on polymorphisms in genes such as UCP2, UCP3, 5-HT2C, MC4R, FKBP5, FTO, CAT haplotypes, LYPAL-1, PTEN, FABP-2, CNR1, LEP656, LEP223, GLP-1R, APOA-1, APOE, ADIPOQ, IL-6, PGC1a, TM6SF2, MBOAT7, PNPLA3, TCF7L2, ESR1, GHSR, GHRL, CD40L, DIO2, ACSL5, CG, TAS2R38, CD36, OBPIIa, NPY, BDNF, CLOCK, and CAMKK2. Most studies explored associations with post-surgery weight loss, while some examined metabolic, cardiovascular, taste, and eating behavior effects as well. Understanding the role of genetic factors in weight loss and metabolic outcomes post-MBS can help tailor personalized treatment plans for improved efficacy and long-term success. Further research with larger sample sizes and extended follow-up is needed to clarify the effects of many genetic variants on MBS outcomes in morbidly obese patients. |
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| Keywords: | obesity, morbid obesity, metabolic and bariatric surgery, genetic variant, polymorphism, single nucleotide polymorphism |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-24 |
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| Numbering: | Vol. 16, iss. 15, [article no.] 2510 |
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| PID: | 20.500.12556/DiRROS-30112  |
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| UDC: | 616-07 |
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| ISSN on article: | 2072-6643 |
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| DOI: | 10.3390/nu16152510 |
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| COBISS.SI-ID: | 203541763 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 5. 8. 2024;
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| Publication date in DiRROS: | 15.06.2026 |
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| Views: | 171 |
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| Downloads: | 114 |
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