| Title: | Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology |
|---|
| Authors: | ID Kac, Przemyslaw R. (Author)
ID Gonzalez-Ortiz, Fernando (Author)
ID Emeršič, Andreja (Author)
ID Dulewicz, Maciej (Author)
ID Koutarapu, Srinivas (Author)
ID Turton, Michael (Author)
ID An, Yang (Author)
ID Smirnov, Denis (Author)
ID Kulczyńska-Przybik, Agnieszka (Author)
ID Varma, Vijay R. (Author)
ID Gregorič Kramberger, Milica (Author)
ID Čučnik, Saša (Author)
ID Rot, Uroš (Author), et al. |
|---|
| Files: |  PDF - Presentation file, download (2,04 MB)
MD5: E900D689A16F0E2A911E05E5E3120E3F
 URL - Source URL, visit https://www.nature.com/articles/s41467-024-46876-7
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212. In five cohorts (n = 388 participants), plasma p-tau212 showed high performances for AD diagnosis and for the detection of both amyloid and tau pathology, including at autopsy as well as in memory clinic populations. The diagnostic accuracy and fold changes of plasma p-tau212 were similar to those for p-tau217 but higher than p-tau181 and p-tau231. Immunofluorescent staining of brain tissue slices showed prominent p-tau212 reactivity in neurofibrillary tangles that co-localized with p-tau217 and p-tau202/205. These findings support plasma p-tau212 as a peripherally accessible biomarker of AD pathophysiology. |
|---|
| Keywords: | plasma p-tau212, diagnostics, Alzheimer disease, neuropathology |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2024 |
|---|
| Number of pages: | str. 1-16 |
|---|
| Numbering: | Vol. 15, iss. [article no.] 2615 |
|---|
| PID: | 20.500.12556/DiRROS-30091  |
|---|
| UDC: | 616.8 |
|---|
| ISSN on article: | 2041-1723 |
|---|
| DOI: | 10.1038/s41467-024-46876-7 |
|---|
| COBISS.SI-ID: | 192269315 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 4. 2024;
|
|---|
| Publication date in DiRROS: | 15.06.2026 |
|---|
| Views: | 186 |
|---|
| Downloads: | 122 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
