| Title: | Markers of mitochondrial injury and neurological outcomes of comatose patients after cardiac arrest : Elektronski vir |
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| Authors: | ID Živanovič, Ina (Author)
ID Miš, Katarina (Author)
ID Pirkmajer, Sergej (Author)
ID Marić, Ivica (Author)
ID Goslar, Tomaž (Author) |
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| Files: |  PDF - Presentation file, download (350,75 KB)
MD5: 13232C352BA548A35689E8F7DE4038DD
 URL - Source URL, visit https://www.mdpi.com/1648-9144/60/8/1286
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background and Objectives: Most patients who are successfully resuscitated from cardiac arrest remain comatose, and only half regain consciousness 72 h after the arrest. Neuroprognostication methods can be complex and even inconclusive. As mitochondrial components have been identified as markers of post-cardiac-arrest injury and associated with survival, we aimed to investigate cytochrome c and mtDNA in comatose patients after cardiac arrest to compare neurological outcomes and to evaluate the markers' neuroprognostic value. Materials and Methods: This prospective observational study included 86 comatose post-cardiac-arrest patients and 10 healthy controls. Cytochrome c and mtDNA were determined at admission. Neuron-specific enolase (NSE) was measured after 72 h. Additional neuroprognostication methods were performed when patients remained unconscious. Cerebral performance category (CPC) was determined. Results: Cytochrome c was elevated in patients compared to healthy controls (2.029 [0.85-4.97] ng/mL vs. 0 [0.0-0.16], p < 0.001) but not mtDNA (95,228 [52,566-194,060] vs. 41,466 [28,199-104,708] copies/μL, p = 0.074). Compared to patients with CPC 1-2, patients with CPC 3-5 had higher cytochrome c (1.735 [0.717-3.40] vs. 4.109 [1.149-8.457] ng/mL, p = 0.011), with no differences in mtDNA (87,855 [47,598-172,464] vs. 126,452 [69,447-260,334] copies/μL, p = 0.208). Patients with CPC 1-2 and CPC 3-5 differed in all neuroprognostication methods. In patients with good vs. poor neurological outcome, ROC AUC was 0.664 (p = 0.011) for cytochrome c, 0.582 (p = 0.208) for mtDNA, and 0.860 (p < 0.001) for NSE. The correlation between NSE and cytochrome c was moderate, with a coefficient of 0.576 (p < 0.001). Conclusions: Cytochrome c was higher in comatose patients after cardiac arrest compared to healthy controls and higher in post-cardiac-arrest patients with poor neurological outcomes. Although cytochrome c correlated with NSE, its neuroprognostic value was poor. We found no differences in mtDNA. |
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| Keywords: | cardiac arrest, cytochrome c, mitochondria, mtDNA, neuroprognostication |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-13 |
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| Numbering: | Vol. 60, iss. 8, [article no.] 1286 |
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| PID: | 20.500.12556/DiRROS-30058  |
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| UDC: | 616.1 |
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| ISSN on article: | 1648-9144 |
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| DOI: | 10.3390/medicina60081286 |
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| COBISS.SI-ID: | 207431427 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 13. 9. 2024;
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| Publication date in DiRROS: | 12.06.2026 |
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| Views: | 92 |
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| Downloads: | 66 |
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