| Title: | Real-world data on the minimed 780G advanced hybrid closed-loop system use during type 1 diabetes pregnancy : one centre observational study |
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| Authors: | ID Munda, Ana (Author)
ID Kovacic, Chiara (Author)
ID Pongrac Barlovič, Draženka (Author) |
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| Files: |  PDF - Presentation file, download (822,80 KB)
MD5: A0B837434E99FDA037C794FF7E59A763
 URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S1056872724001211
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Aim The efficacy of hybrid closed-loop systems (HCLs) in managing glycemic control in pregnant women with type 1 diabetes remains inadequately characterized. We evaluated the use of the Medtronic Minimed 780G HCLs. Methods: The retrospective observational study analyzed the glycemic and perinatal outcomes of pregnant women using the HCLs, followed at our tertiary centre. Independent t-tests were employed to compare data among trimesters based on pre-pregnancy HbA1c. The associations between glycemic parameters and perinatal outcomes were explored using Spearman rho. Results: Among the 21 women (age: 33.5 ± 4.2 years, diabetes duration: 21.2 ± 7.6 years, pre-pregnancy HbA1c 7.0 ± 1.1 % (52.9 ± 11.9 mmol/mol)) time in range (pTIR, 63–140 mg/dl; 3.5–7.8 mmol/l) increased progressively throughout pregnancy (trimesters: first: 64.0 ± 9.0 %; second:71.3 ± 11.8 %; third: 75.7 ± 8.1 %). Simultaneously, mean sensor glucose decreased (trimesters: first: 130 ± 10.4 mg/dl (7.2 ± 0.6 mmol/l); second: 120.9 ± 13.4 mg/dl (6.7 ± 0.7 mmol/l); third: 117.3 ± 9.1 mg/dl (6.5 ± 0.5 mmol/l)). Although a majority of women achieved the target pTIR until the third trimester, this did not consistently prevent the delivery of a largefor-gestational-age baby. Notably, one ketoacidosis event occurred, and there were no reported instances of severe hypoglycemia. Conclusion: Use of the Minimed 780G HCLs enabled the attainment of recommended pregnancy glycemic targets for most women with type 1 diabetes in a real-world setting. |
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| Keywords: | Type 1 diabetes, pregnancy continuous glucose monitoring, closed-loop insulin delivery |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-7 |
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| Numbering: | Vol. 38, iss. 8, [article no.] 108795 |
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| PID: | 20.500.12556/DiRROS-30020  |
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| UDC: | 616.379 |
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| ISSN on article: | 1873-460X |
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| DOI: | 10.1016/j.jdiacomp.2024.108795 |
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| COBISS.SI-ID: | 200991491 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 8. 7. 2024;
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| Publication date in DiRROS: | 11.06.2026 |
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| Views: | 132 |
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| Downloads: | 135 |
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