| Title: | Retinal ganglion cell function and perfusion following intraocular pressure reduction with preservative-free latanoprost in patients with glaucoma and ocular hypertension |
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| Authors: | ID Daka, Qëndresë (Author)
ID Šuštar Habjan, Maja (Author)
ID Meglič, Andrej (Author)
ID Perovšek, Darko (Author)
ID Atanasovska Velkovska, Makedonka (Author)
ID Cvenkel, Barbara (Author) |
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| Files: |  PDF - Presentation file, download (411,02 KB)
MD5: 6B84EB4B786C2D84CB1FB763F55136DC
 URL - Source URL, visit https://www.mdpi.com/2077-0383/13/5/1226
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | (1) Background: Given the global prevalence of glaucoma and the crucial role of intraocular pressure (IOP) reduction in the management of the disease, understanding the immediate effects on retinal structure and function is essential. (2) Methods: This study aimed to assess the effects of preservative-free latanoprost on morphological and functional parameters in treatment-naïve patients with ocular hypertension and open-angle glaucoma. (3) Results: This study showed a significant reduction in IOP by an average of 30.6% after treatment with preservative-free latanoprost. Despite the significant reduction in IOP, no statistically significant changes were observed in the electroretinogram (ERG) nor the optical coherence tomography/angiography (OCT/OCTA) parameters compared to baseline. An exploration of the correlation between IOP changes and various parameters revealed a significant association solely with the macular IPL/INL plexus vessel density (VD) measured with OCTA. (4) Conclusions: This finding suggests a possible association between IOP reduction and changes in the macular microcirculation and provides valuable insights into the differential effects of latanoprost. Acknowledging the study limitations, this study emphasizes the need for larger, longer-term investigations to comprehensively assess the sustained effects of preservative-free latanoprost on both IOP and retinal parameters. In addition, exploring systemic factors and conducting subgroup analyses could improve personalized approaches to glaucoma treatment. |
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| Keywords: | electroretinogram, optical coherence tomography, optical coherence tomography angiography, preservative-free latanoprost, retinal ganglion cell |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-12 |
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| Numbering: | Vol. 13, iss. 5, [article no.] 1226 |
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| PID: | 20.500.12556/DiRROS-30012  |
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| UDC: | 617.7 |
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| ISSN on article: | 2077-0383 |
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| DOI: | 10.3390/jcm13051226 |
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| COBISS.SI-ID: | 195118595 |
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| Note: |
Nasl. z nasl. zaslona;
Opis vira z dne 13. 5. 2024;
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| Publication date in DiRROS: | 11.06.2026 |
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| Views: | 117 |
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| Downloads: | 69 |
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