| Title: | FLAG/FLAG-Ida Regimen in secondary and relapsed/refractory acute myeloid leukemia—even in the era of new treatment modalities still a significant player |
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| Authors: | ID Anžej Doma, Saša (Author)
ID Sever, Matjaž (Author)
ID Jakoš, Gorazd (Author)
ID Podgornik, Helena (Author) |
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| Files: |  PDF - Presentation file, download (1,07 MB)
MD5: 39DDCB9E626A816CE51C3CD4DF02A908
 URL - Source URL, visit https://www.mdpi.com/2077-0383/13/7/1842
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Abstract: (1) Background: Relapsed/refractory (r/r) and secondary acute myeloid leukemia are highlighted by chemoresistance and poor outcomes. The aim of the study was to assess the efficacy and toxicity of fludarabine, cytarabine, and granulocyte-colony stimulation factor (FLAG) with or without idarubicin (-Ida) and to discuss novel therapies in this setting. (2) Methods: Clinical and cytogenetic data on 130 consecutive patients with r/r and secondary AML treated at our center were retrospectively analyzed. (3) Results: There were 48, 56, and 26 patients with relapsed, refractory, and secondary AML, respectively. The median age was 60 years. The overall response was achieved in 70% of patients. The median overall survival (OS) time for the whole group was 9.4 months. In total, 47% of patients proceeded to allogeneic hematopoietic stem cell transplantation (aHSCT) and these patients had significantly prolonged OS compared to the others (63 months vs. 4.2 months; p < 0.001). Among the variables, including age, FLT3 mutation status, European LeukemiaNet (ELN) 2022 classification risk, FLAG vs. FLAG-Ida, and aHSCT, a multivariate analysis revealed that only aHSCT significantly influenced overall survival. (4) Conclusions: FLAG(-Ida) chemotherapy remains an effective salvage chemotherapy for patients with r/r and secondary AML with a plan of proceeding to aHSCT. |
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| Keywords: | relapsed/refractory AML, secondary AML, FLAG-Ida, FLAG, FLT3 mutation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-10 |
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| Numbering: | Vol. 13, iss. 2, [article no.] 1842 |
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| PID: | 20.500.12556/DiRROS-30010  |
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| UDC: | 61 |
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| ISSN on article: | 2077-0383 |
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| DOI: | 10.3390/jcm13071842 |
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| COBISS.SI-ID: | 190952195 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 29. 3. 2024;
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| Publication date in DiRROS: | 11.06.2026 |
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| Views: | 45 |
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| Downloads: | 33 |
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