| Title: | Genetic variability of incretin receptors affects the occurrence of neurodegenerative diseases and their characteristics |
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| Authors: | ID Vogrinc, David (Author)
ID Redenšek Trampuž, Sara (Author)
ID Blagus, Tanja (Author)
ID Trošt, Maja (Author)
ID Gregorič Kramberger, Milica (Author)
ID Emeršič, Andreja (Author)
ID Čučnik, Saša (Author)
ID Goričar, Katja (Author)
ID Dolžan, Vita (Author) |
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| Files: |  PDF - Presentation file, download (556,43 KB)
MD5: 67B044D97FA9F59D1773FFFDFF143122
 URL - Source URL, visit https://www.cell.com/action/showPdf?pii=S2405-8440%2824%2915188-2
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases. Their treatment options are rather limited, and no neuroprotective or disease-modifying treatments are available. Anti-diabetic drugs, such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) agonists, have been suggested as a potential therapeutic option. Aims: Assess GLP1R and GIPR genetic variability in relation to AD- and PD-related phenotypes. Methods: AD, PD patients and healthy control subjects were included in the study. Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease were measured in AD patients, while cognitive impairment was evaluated in PD. All participants were genotyped for three SNPs: GLP1R rs10305420, GLP1R rs6923761 and GIPR rs1800437. Results: GLP1R rs10305420 genotypes were associated with increased odds for AD and PD development. GLP1R rs10305420 and GLP1R rs6923761 genotypes were significantly associated with Aβ42/40 ratio (p = 0.041 and p = 0.050), while GLP1R rs6923761 was also associated with p-tau levels (p = 0.022). Finally, GIPR rs1800437 heterozygotes as well as carriers of at least one GIPR rs1800437 C allele presented with increased odds for the development of dementia in PD (OR = 1.92; 95 % CI = 1.05-3.51; p = 0.034 and OR = 1.95; 95 % CI = 1.08-3.52; p = 0.027, respectively). Conclusion: GLP1R and GIPR genetic variability may affect the occurrence of AD and PD and is also associated with AD CSF biomarkers for Alzheimer's disease and dementia in PD. The data on GLP1R and GIPR genetic variability may support the function of incretin receptors in neurodegeneration. |
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| Keywords: | Alzheimer's disease, biomarker, glucagon-like peptide 1 receptor, glucose-dependent insulinotropic polypeptide, Parkinson's disease, polymorphism |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Vol. 10, iss. 20, [article no.] e39157 |
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| PID: | 20.500.12556/DiRROS-29934  |
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| UDC: | 616.8:577 |
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| ISSN on article: | 2405-8440 |
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| DOI: | 10.1016/j.heliyon.2024.e39157 |
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| COBISS.SI-ID: | 214994947 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 11. 2024;
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| Publication date in DiRROS: | 09.06.2026 |
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| Views: | 120 |
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| Downloads: | 87 |
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