| Title: | Unraveling the role of IL-17 in lichen planus : a comparative investigation of clinical variability and immunopathogenic pathways |
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| Authors: | ID Tolušić Levak, Maja (Author)
ID Pauzar, Mirta (Author)
ID Plužarić, Vera (Author)
ID Francesch, Nika (Author)
ID Pauzar, Biljana (Author)
ID Rajc, Jasmina (Author)
ID Delaš Aždajić, Marija (Author)
ID Mihalj, Martina (Author) |
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| Files: |  URL - Source URL, visit https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.14/actaapa.2025.14.pdf
 PDF - Presentation file, download (24,39 MB)
MD5: 46ADC2DE312AC96841B9B9E70937F422
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZSD - Association of Slovenian Dermatovenereologists
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| Abstract: | Introduction: Lichen planus (LP) is a chronic T cell–mediated inflammatory disease affecting the skin and mucosa. Interleukin-17 (IL-17), a pro-inflammatory cytokine, has been implicated in LP pathogenesis, but its tissue-level expression across clinical variants remains underexplored. This study compares IL-17 expression in healthy skin and LP lesions and assesses variations based on clinical presentation. Methods: This cross-sectional retrospective study included 20 LP skin samples and 10 healthy controls. The sample collection spanned a period of 10 years. IL-17 expression was assessed via immunohistochemistry and quantified using a modified Q score. Samples were categorized by mucosal involvement and lesion distribution. Statistical analysis was performed with the MannWhitney U test. Results: IL-17 was absent in healthy skin but present in all LP samples. IL-17 expression was significantly higher in patients with both skin and oral mucosal involvement compared to those with cutaneous LP (p = 0.003). No significant difference was observed between generalized and localized LP. Conclusions: The results indicate a distinct increase in IL-17 expression in LP lesions, particularly with mucosal involvement, supporting its role in LP pathogenesis. These findings suggest IL-17 as a potential biomarker and therapeutic target, warranting further investigation in larger cohorts. |
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| Keywords: | inflammatory dermatoses, lichen planus, interleukin-17, immunoexpression |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.06.2025 |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 51-54 |
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| Numbering: | Vol. 34, issue 2 |
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| PID: | 20.500.12556/DiRROS-29904  |
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| UDC: | 616.5:579 |
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| ISSN on article: | 1318-4458 |
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| DOI: | 10.15570/actaapa.2025.14 |
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| COBISS.SI-ID: | 260270851 |
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| Publication date in DiRROS: | 15.06.2026 |
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| Views: | 45 |
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| Downloads: | 19 |
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