| Title: | Treatment of alopecia areata with JAK inhibitors : a review of the literature |
|---|
| Authors: | ID Townsend, Jaiden (Author)
ID Godić, Aleksandar (Author) |
|---|
| Files: |  URL - Source URL, visit https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2025.22/actaapa.2025.22.pdf
 PDF - Presentation file, download (13,41 MB)
MD5: B731590518F0D2360C0CB5DA090A10E6
|
|---|
| Language: | English |
|---|
| Typology: | 1.02 - Review Article |
|---|
| Organization: |  ZSD - Association of Slovenian Dermatovenereologists
|
|---|
| Abstract: | Alopecia areata (AA) is chronic autoimmune non-scarring hair loss, which can progress to alopecia totalis or universalis. Conventional treatments, such as corticosteroids and immunotherapies, often offer limited temporary benefits in moderate to severe cases. Recent advances have identified Janus kinase (JAK) inhibitors as a promising therapeutic option, targeting cytokine pathways involved in AA pathogenesis. This review explores the current evidence surrounding JAK inhibitors in the management of AA. Clinical trials and case series have demonstrated notable efficacy in promoting hair regrowth, even in extensive disease. Baricitinib and deuruxolitinib have shown particularly strong results, with significant scalp hair regrowth and acceptable safety profiles. Common adverse effects include acne, elevated lipid levels, and mild laboratory abnormalities, although long-term data remain limited. This review summarizes the mechanisms, efficacy outcomes, and safety data of various JAK inhibitors used in AA and highlights the need for further research to establish optimal dosing, treatment duration, and long-term safety. |
|---|
| Keywords: | alopecia, alopecia areata, dermatology, hair disorder, JAK |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 18.06.2025 |
|---|
| Article acceptance date: | 31.07.2025 |
|---|
| Publication date: | 01.09.2025 |
|---|
| Place of publishing: | Ljubljana |
|---|
| Publisher: | Združenje slovenskih dermatovenerologov |
|---|
| Year of publishing: | 2025 |
|---|
| Number of pages: | str. 117-120 |
|---|
| Numbering: | Vol. 34, issue 3 |
|---|
| PID: | 20.500.12556/DiRROS-29895  |
|---|
| UDC: | 616.5:579 |
|---|
| ISSN on article: | 1318-4458 |
|---|
| DOI: | 10.15570/actaapa.2025.22 |
|---|
| COBISS.SI-ID: | 260106499 |
|---|
| Copyright: | Na spletni strani revije navedeno: Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ISSN 1318-4458) is an open access medical journal published quarterly by the Association of Slovenian Dermatovenerologists (https://acta-apa.mf.uni-lj.si/index.php); Authors publishing in our journal retain copyright of their work under the Creative Commons Attribution License (CC BY 4.0). This license allows unrestricted use, distribution, and reproduction of the work in any medium, provided the original author(s) and copyright holder(s) are appropriately credited, and the original publication in the journal is properly cited, following established academic practices (https://acta-apa.mf.uni-lj.si/submissions.php). |
|---|
| Publication date in DiRROS: | 15.06.2026 |
|---|
| Views: | 195 |
|---|
| Downloads: | 168 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
