| Title: | Maternal APOE [epsilon]2 as a possible risk factor for elevated prenatal Pb levels |
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| Authors: | ID Palir, Neža (Author)
ID Stajnko, Anja (Author)
ID Mazej, Darja (Author)
ID France Štiglic, Alenka (Author)
ID Snoj Tratnik, Janja (Author)
ID Runkel, Agneta Annika (Author)
ID Marc, Janja (Author)
ID Horvat, Milena (Author)
ID Falnoga, Ingrid (Author), et al. |
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| Files: |  PDF - Presentation file, download (4,62 MB)
MD5: A2D26D2BF4A0BB79D1A8507027AB6D01
 URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0013935124014889
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure. |
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| Keywords: | cord blood, maternal APOE ε2 allele, bone turnover, fetal sex, parity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-12 |
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| Numbering: | Vol. 260, [article no.] 119583 |
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| PID: | 20.500.12556/DiRROS-29805  |
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| UDC: | 504.5 |
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| ISSN on article: | 1096-0953 |
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| DOI: | 10.1016/j.envres.2024.119583 |
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| COBISS.SI-ID: | 202005507 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 7. 2024;
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| Publication date in DiRROS: | 05.06.2026 |
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| Views: | 30 |
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| Downloads: | 14 |
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