| Title: | Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity |
|---|
| Authors: | ID Aregay, Amare (Author)
ID Slunečko, Jan (Author)
ID Bogovič, Petra (Author)
ID Korva, Miša (Author)
ID Resman Rus, Katarina (Author)
ID Knap, Nataša (Author)
ID Beicht, Jana (Author)
ID Kubinski, Mareike (Author)
ID Saletti, Giulietta (Author)
ID Steffen, Imke (Author)
ID Strle, Franc (Author)
ID Avšič-Županc, Tatjana (Author), et al. |
|---|
| Files: |  PDF - Presentation file, download (1,44 MB)
MD5: C86B86112046F463476F978B7A71BD67
 URL - Source URL, visit https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2317909
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortly after infection, with clinical manifestations, severity and long-term outcome has been poorly investigated. In a cohort of thirty early tick-borne encephalitis (TBE) patients, we assessed the magnitude, specificity and functional properties of TBEV-specific T-cell and antibody responses. These responses early during disease were assessed in view of clinical manifestations, severity and long-term outcome. TBEV-specific T-cell responses to C, E, NS1, and NS5 proteins were significantly lower in patients with severe acute illness than in patients with mild TBE. Lower T-cell responses to E, NS1, and NS5 proteins also correlated with the development of meningoencephalomyelitis. Virus-specific antibody titres early after infection did not correlate with disease severity, clinical manifestations, or long-term outcome in this study, possibly due to the small number of patients of which matching serum and peripheral blood mononuclear cells were available. The findings suggest that virus-specific T cells afford a certain degree of protection against the development of severe TBEV-induced disease. |
|---|
| Keywords: | TBEV, tick-borne encephalitis (TBE), TBEV-specific T-cells, disease severity, outcome |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2024 |
|---|
| Number of pages: | str. 1-10 |
|---|
| Numbering: | Vol. 13, iss. 1, [article no.] 2317909 |
|---|
| PID: | 20.500.12556/DiRROS-29803  |
|---|
| UDC: | 616.9 |
|---|
| ISSN on article: | 2222-1751 |
|---|
| DOI: | 10.1080/22221751.2024.2317909 |
|---|
| COBISS.SI-ID: | 189011971 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 3. 2024;
|
|---|
| Publication date in DiRROS: | 05.06.2026 |
|---|
| Views: | 30 |
|---|
| Downloads: | 12 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
