| Title: | Defining remission in childhood-onset lupus : PReS-endorsed consensus definitions by an international task force |
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| Authors: | ID Smith, Eve Mary Dorothy (Author)
ID Aggarwal, Amita (Author)
ID Ainsworth, Jenny (Author)
ID Al-Abadi, Eslam (Author)
ID Avčin, Tadej (Author)
ID Bortey, Lynette (Author)
ID Burnham, Jon (Author)
ID Ciurtin, Coziana (Author)
ID Hedrich, Christian M. (Author)
ID Kamphuis, Sylvia (Author), et al. |
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| Files: |  PDF - Presentation file, download (767,89 KB)
MD5: 123E1FD34CC7DDAA26DDA6C4B78AE164
 URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S1521661624001050
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Method:s The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research. |
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| Keywords: | autoinflammatory diseases, lupus, treat-to-target, remission, children |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Vol 263 |
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| PID: | 20.500.12556/DiRROS-29776  |
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| UDC: | 616-097 |
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| ISSN on article: | 1521-6616 |
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| DOI: | 10.1016/j.clim.2024.110214 |
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| COBISS.SI-ID: | 205657859 |
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| Note: |
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| Publication date in DiRROS: | 05.06.2026 |
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| Views: | 51 |
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| Downloads: | 30 |
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