| Title: | Change in cardiovascular health and rate of cognitive decline in older adults : a 15-year population-based study |
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| Authors: | ID Špeh, Andreja (Author)
ID Gregorič Kramberger, Milica (Author)
ID Winblad, Bengt (Author)
ID Backman, Lars (Author)
ID Qiu, Chengxuan (Author)
ID Laukka, Erika J. (Author) |
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| Files: |  PDF - Presentation file, download (1,13 MB)
MD5: C7E3AEA1D5919AF3BFC5B6011652E9CA
 URL - Source URL, visit https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-024-04856-y
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background Previous research on associations between cardiovascular health, measured at a single timepoint, and rate of age-related cognitive decline shows divergent findings dependent on the participants’ age and the health metric studied. The aim of this study was to add to the knowledge in this field by investigating whether change in cardiovascular health, assessed with Life’s Simple 7 (LS7) score, is associated with rate of cognitive change in youngold and old-old adults. Methods The study included 1022 participants aged≥60 years from the Swedish National Study on Aging and CareKungsholmen (SNAC-K), who underwent repeated neuropsychological testing (episodic memory, semantic memory, verbal fluency, and perceptual speed) across up to 15 years. LS7, composed of seven cardiovascular health metrics (smoking, diet, physical activity, body mass index, plasma glucose, total serum cholesterol, and blood pressure), was assessed at baseline and at the 6-year follow-up. Change in LS7 was calculated as the difference between baseline and 6 years (range −5 to 8 points) and categorised into worse (−5 to −2 points), stable (−1 to 1 points), and improved (2 to 8 points). Change in cognitive performance as a function of LS7 change categories was estimated using linear mixed-effects models. Results Participants were classified as stable (67.1%), improved (21.0%), or worse (11.8%) according to changes in LS7 score. Both the worse and improved categories were associated with faster cognitive decline. Age-stratified analyses revealed that worsening of LS7 was clearly associated with faster cognitive decline in the old-old (≥78 years), whereas improvement tended be associated with faster cognitive decline in the young-old (<78 years) group. Conclusions Change in cardiovascular health in old age may lead to accelerated cognitive decline, particularly in late senescence. These results suggest that it is important to monitor and maintain cardiovascular health status in very old adults. |
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| Keywords: | aging, cardiovascular risk factors, cognition, epidemiology |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-10 |
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| Numbering: | Vol. 24, iss. 1 |
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| PID: | 20.500.12556/DiRROS-29744  |
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| UDC: | 617 |
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| ISSN on article: | 1471-2318 |
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| DOI: | 10.1186/s12877-024-04856-y |
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| COBISS.SI-ID: | 200307459 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 1. 7. 2024;
Članek št. 263;
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| Publication date in DiRROS: | 04.06.2026 |
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| Views: | 77 |
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| Downloads: | 47 |
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