| Title: | Dynamics of leukocyte telomere length in patients with Fabry disease |
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| Authors: | ID Levstek, Tina (Author)
ID Breznik, Nika (Author)
ID Vujkovac, Bojan (Author)
ID Nowak, Albina (Author)
ID Trebušak Podkrajšek, Katarina (Author) |
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| Files: |  PDF - Presentation file, download (731,45 KB)
MD5: A759E4D57021AA05463423E5FC00CA8F
 URL - Source URL, visit https://www.mdpi.com/2227-9059/12/8/1724
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Fabry disease (FD) leads to significant morbidity and mortality, which may indicate accelerated ageing. However, it is still unclear whether there is a relationship between telomere length (TL), a marker of biological ageing, and disease outcome. We aimed to examine the relationship between leukocyte TL (LTL) dynamics and the presence of advanced disease stages and/or late complications of FD, including hypertrophic cardiomyopathy, nephropathy and stroke, both cross-sectionally and longitudinally. DNA was extracted from peripheral blood leukocytes and quantitative PCR was utilized to determine relative LTL in 99 Fabry patients. In the longitudinal analysis, we included 50 patients in whom at least three measurements were performed over a period of 5–10 years. The results showed a significant inverse correlation between LTL and age (ρ = −0.20, p = 0.05). No significant differences in LTL were found between females and males (p = 0.79) or between patients receiving disease-specific therapy and those without (p = 0.34). In a cross-sectional analysis, no association was found between the presence (p = 0.15) or number (p = 0.28) of advanced stages of the disease and/or late complications and LTL. Similarly, in a longitudinal analysis, no difference in LTL dynamics was found regarding the presence (p = 0.16) of advanced stage organ involvement and/or late complications or their number. These findings indicate that LTL dynamics in adulthood may not be a reliable indicator of disease outcomes in Fabry patients. Therefore, LTL may more accurately reflect the disease burden in early life, when TL is primarily determined. |
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| Keywords: | Fabry disease, telomere length, hyperthropic cardiomyopathy, nephropathy, stroke |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Vol. 12, iss. 8, [article no.] 1724 |
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| PID: | 20.500.12556/DiRROS-29735  |
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| UDC: | 616-07 |
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| ISSN on article: | 2227-9059 |
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| DOI: | 10.3390/biomedicines12081724 |
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| COBISS.SI-ID: | 203575043 |
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| Note: |
Nasl. z nasl. zaslona;
Opis vira z dne 5. 8. 2024;
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| Publication date in DiRROS: | 04.06.2026 |
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| Views: | 72 |
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| Downloads: | 48 |
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