| Title: | Cerebrospinal fluid p-tau181, 217, and 231 in definite Creutzfeldt-Jakob disease with and without concomitant pathologies |
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| Authors: | ID Emeršič, Andreja (Author)
ID Ashton, Nicholas J. (Author)
ID Vrillon, Agathe (Author)
ID Lantero-Rodriguez, Juan (Author)
ID Mlakar, Jernej (Author)
ID Gregorič Kramberger, Milica (Author)
ID Gonzalez-Ortiz, Fernando (Author)
ID Kac, Przemyslaw R. (Author)
ID Dulewicz, Maciej (Author)
ID Hanrieder, Jörg (Author)
ID Rot, Uroš (Author)
ID Čučnik, Saša (Author), et al. |
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| Files: |  PDF - Presentation file, download (1,02 MB)
MD5: D9031F3C7ACB542A97CDD90B46A585FF
 URL - Source URL, visit https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13907
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Introduction: The established cerebrospinal fluid (CSF) phosphorylated tau181 (p-tau181) may not reliably reflect concomitant Alzheimer's disease (AD) and primary age-related tauopathy (PART) found in Creutzfeldt-Jakob disease (CJD) at autopsy. Methods: We investigated CSF N-terminal p-tau181, p-tau217, and p-tau231 with in-house Simoa assays in definite CJD (n = 29), AD dementia (n = 75), mild cognitive impairment (MCI) due to AD (n = 65), and subjective cognitive decline (SCD, n = 28). Post-mortem examination performed in patients with CJD 1.3 (0.3-14.3) months after CSF collection revealed no co-pathology in 10, concomitant AD in 8, PART in 8, and other co-pathologies in 3 patients. Results: N-terminal p-tau was increased in CJD versus SCD (p < 0.0001) and correlated with total tau (t-tau) in the presence of AD and PART co-pathology (rho = 0.758-0.952, p ≤ 001). Concentrations in CJD+AD were indistinguishable from AD dementia, with the largest fold-change in p-tau217 (11.6), followed by p-tau231 and p-tau181 (3.2-4.5). Discussion: Variable fold-changes and correlation with t-tau suggest that p-tau closely associates with neurodegeneration and concomitant AD in CJD. Highlights: N-terminal phosphorylated tau (p-tau) biomarkers are increased in Creutzfeldt-Jakob disease (CJD) with and without concomitant AD. P-tau217, p-tau231, and p-tau181 correlate with total tau (t-tau) and increase in the presence of amyloid beta (Aβ) co-pathology. N-terminal p-tau181 and p-tau231 in Aβ-negative CJD show variation among PRNP genotypes. Compared to mid-region-targeting p-tau181, cerebrospinal fluid (CSF) N-terminal p-tau has greater potential to reflect post-mortem neuropathology in the CJD brain. |
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| Keywords: | Alzheimer's disease, Creutzfeldt–Jakob disease, cerebrospinal fluid, concomitant pathology, neuropathology, phosphorylated tau, p-tau181, p-tau217, p-tau231 |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 5324-5337 |
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| Numbering: | Vol. 20, iss. 8, [article no.] 13907 |
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| PID: | 20.500.12556/DiRROS-29696  |
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| UDC: | 616.8 |
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| ISSN on article: | 1552-5279 |
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| DOI: | 10.1002/alz.13907 |
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| COBISS.SI-ID: | 200801283 |
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| Note: |
Nasl. z nasl. zaslona;
Opis vira z dne 5. 7. 2024;
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| Publication date in DiRROS: | 03.06.2026 |
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| Views: | 146 |
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| Downloads: | 90 |
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