| Title: | Borrelia PeptideAtlas : a proteome resource of common Borrelia burgdorferi isolates for Lyme research |
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| Authors: | ID Reddy, Panga J. (Author)
ID Sun, Zhi (Author)
ID Wippel, Helisa H. (Author)
ID Baxter, David H. (Author)
ID Swearingen, Kristian (Author)
ID Shteynberg, David D. (Author)
ID Midha, Mukul K. (Author)
ID Caimano, Melissa J. (Author)
ID Strle, Klemen (Author)
ID Choi, Yongwook (Author), et al. |
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| Files: |  PDF - Presentation file, download (4,63 MB)
MD5: F55F4C8C901C2D520343FD40AF55D09C
 URL - Source URL, visit https://www.nature.com/articles/s41597-024-04047-9
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Lyme disease is caused by an infection with the spirochete Borrelia burgdorferi, and is the most common vector-borne disease in North America. B. burgdorferi isolates harbor extensive genomic and proteomic variability and further comparison of isolates is key to understanding the infectivity of the spirochetes and biological impacts of identified sequence variants. Here, we applied both transcriptome analysis and mass spectrometry-based proteomics to assemble peptide datasets of B. burgdorferi laboratory isolates B31, MM1, and the infective isolate B31-5A4, to provide a publicly available Borrelia PeptideAtlas. Included are total proteome, secretome, and membrane proteome identifications of the individual isolates. Proteomic data collected from 35 different experiment datasets, totaling 386 mass spectrometry runs, have identified 81,967 distinct peptides, which map to 1,113 proteins. The Borrelia PeptideAtlas covers 86% of the total B31 proteome of 1,291 protein sequences. The Borrelia PeptideAtlas is an extensible comprehensive peptide repository with proteomic information from B. burgdorferi isolates useful for Lyme disease research. |
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| Keywords: | Borrelia burgdorferi, Lyme disease, peptide repository, proteomic data |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | 17 str. |
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| Numbering: | Vol. 11, [article no.] ǂ1313 |
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| PID: | 20.500.12556/DiRROS-29654  |
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| UDC: | 616.9 |
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| ISSN on article: | 2052-4463 |
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| DOI: | 10.1038/s41597-024-04047-9 |
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| COBISS.SI-ID: | 279370243 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 5. 2026;
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| Publication date in DiRROS: | 02.06.2026 |
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| Views: | 124 |
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| Downloads: | 85 |
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| Metadata: |    |
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