| Title: | Long-term echocardiographic features after percutaneous closure of patent foramen ovale |
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| Authors: | ID Rojko, Maja (Author)
ID Černič Šuligoj, Nataša (Author)
ID Žvan, Bojana (Author)
ID Zorc, Marjeta (Author)
ID Kar, Saibal (Author)
ID Noč, Marko (Author) |
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| Files: |  PDF - Presentation file, download (961,04 KB)
MD5: C3894EEBA28C855B815ABB07F2CAE411
 URL - Source URL, visit https://www.icrjournal.com/articles/long-term-echocardiographic-features-after-percutaneous-closure-patent-foramen-ovale
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: There is a lack of studies systematically addressing long-term echocardiographic features after patent foramen ovale (PFO) closure. Thus, the present study investigated long-term echocardiographic features after percutaneous closure of PFO. Methods: This was a single-centre observational study based on the institutional registry of consecutive patients undergoing PFO closure. Clinical and echocardiographic features during the follow-up were investigated. Results: Between 2006 and 2023, 355 consecutive patients underwent PFO closure following transitory ischaemic attack (TIA) or cerebrovascular insult (CVI). Echocardiography immediately after the procedure and at 6 months was performed in 306 (86%) patients, who had repeat examinations at either between 1 and 5 years (median 1.32 years), between 5 and 10 years (median 7.10 years) or after 10 years (median 11.64 years). The percentage of patients with complete closure (no bubbles during the Valsalva manoeuvre) increased from 64% after the procedure to 80% at 6 months (p<0.05), and ranged between 77% and 81% thereafter (NS). Functional closure (≤10 bubbles) was observed in 93% of patients after the procedure and remained between 94% and 97% thereafter (NS). Except for decreased immediate complete closure (60% versus 83%; p<0.001), there was no difference between the Amplatzer PFO occluder and alternative devices. Among the 15 patients with greater than moderate residual shunt, reasons for the shunt were determined in 73% of patients and included leakage at the level of device, fenestration/atrial septal defect and pulmonary arteriovenous malformation. There was no late device embolisation, thrombus formation or pericardial effusion. Clinical follow-up revealed recurrent TIA and CVI rates of 0.11 and 0.06 per 100 patient-years, respectively. Conclusion: We demonstrated high (>90%) and persistent functional PFO closure beyond 10 years, independent of closure device. There was no late device embolisation, thrombus formation or pericardial effusion. Favourable echocardiographic features were associated with very low rates of recurrent TIA or CVI. |
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| Keywords: | patent foramen ovale closure, residual shunt, echocardiography |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | 5 str. |
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| Numbering: | Vol. 21, article no. ǂ1 |
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| PID: | 20.500.12556/DiRROS-29609  |
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| UDC: | 616.12 |
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| ISSN on article: | 1756-1485 |
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| DOI: | 10.15420/icr.2025.30 |
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| COBISS.SI-ID: | 278658307 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 5. 2026;
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| Publication date in DiRROS: | 01.06.2026 |
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| Views: | 65 |
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| Downloads: | 43 |
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