| Title: | Spinal mechanisms in post-activation potentiation : facilitation of presynaptic inhibition contrasts h-reflex amplitude reduction |
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| Authors: | ID Kalc, Miloš (Author)
ID Holobar, Aleš (Author)
ID Kramberger, Matej (Author)
ID Murks, Nina (Author)
ID Škarabot, Jakob (Author) |
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| Files: |  PDF - Presentation file, download (12,07 MB)
MD5: A8327996638B887E59315BE2CADE241E
 URL - Source URL, visit https://journals.physiology.org/doi/abs/10.1152/jn.00031.2026
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  ZRS Koper - Science and Research Centre Koper
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| Abstract: | This study invesƟgated the spinal neural mechanisms underlying post‐acƟvaƟon potenƟaƟon in ten16healthy young males (21.9 ± 4.8 years). ParƟcipants performed a 10‐second maximal isometric17plantarflexion, aŌer which we measured twitch torque and assessed spinal excitability using the18soleus H‐reflex, D1 presynapƟc inhibiƟon and heteronymous Ia facilitaƟon (HF). High‐density surface19EMG was decomposed to track single motor unit responses. The condiƟoning contracƟon increased20twitch torque by 12.2 Nm (p < 0.001) immediately and returning to baseline within nine minutes. This21mechanical potenƟaƟon was accompanied by a 29% reducƟon in H‐reflex amplitude (p < 0.001),22which recovered within three minutes. Paradoxically, neurophysiological indices of presynapƟc23inhibiƟon, D1 and HF were significantly increased (D1: p<0.017; HF: p<0.001), resulƟng in spinal24facilitaƟon. Single MU analysis revealed increased discharge probability, parƟcularly in higher‐25threshold units indicaƟng overall spinal facilitaƟon. These results demonstrate that post‐acƟvaƟon26potenƟaƟon involves a complex dissociaƟon: H‐reflex pathway inhibiƟon along with facilitaƟon of27presynapƟc spinal mechanisms. This paradox can be explained by either post‐acƟvaƟon depression28(caused by depleƟon of neurotransmiƩer at the Ia–motoneuron synapse) or muscle thixotropy, a29contracƟon history‐dependent decrease in muscle spindle sensiƟvity, which reduces the efficacy of30the Ia afferent volley independently of spinal inhibitory mechanisms. Our findings highlight a31dissociaƟon between spinal presynapƟc facilitaƟon and the decreased H‐reflex, underscoring the32need for future studies to explicitly test the roles of post‐acƟvaƟon depression and muscle thixotropy33aŌer condiƟoning contracƟons. |
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| Keywords: | HDsEMG, Ia afference, soleus, heteroniumous Ia facilitation, spinal reflex, muscle contraction, neural mechanisms, performance enhancement |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2026 |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-35 |
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| Numbering: | Vol. , iss. |
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| PID: | 20.500.12556/DiRROS-29360  |
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| UDC: | 612.741 |
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| ISSN on article: | 0022-3077 |
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| DOI: | 10.1152/jn.00031.2026 |
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| COBISS.SI-ID: | 277837059 |
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| Copyright: | © 2026 The Authors. |
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| Note: | Soavtorji: Aleš Holobar, Matej Kramberger, Nina Murks, Jakob Škarabot;
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| Publication date in DiRROS: | 12.05.2026 |
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| Views: | 37 |
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| Downloads: | 18 |
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