| Title: | Method development and production of an ambient-stable blood certified reference material for total mercury, methylmercury, and trace elements |
|---|
| Authors: | ID Haraguchi, Koichi (Author)
ID Sakamoto, Mineshi (Author)
ID Nagasaka, Hiromitsu (Author)
ID Horvat, Milena, Institut "Jožef Stefan" (Author)
ID Begu, Ermira, Institut "Jožef Stefan" (Author)
ID Klemenčič, Polona, Institut "Jožef Stefan" (Author)
ID Alilović Osolin, Adna, Institut "Jožef Stefan" (Author)
ID Nakamura, Masaaki (Author), et al. |
|---|
| Files: |  URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0003267026005301?via%3Dihub
 PDF - Presentation file, download (2,72 MB)
MD5: DF66BE6CD967A638FB46895FF553CAA0
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  IJS - Jožef Stefan Institute
|
|---|
| Abstract: | Background. Certified reference materials (CRMs) for mercury speciation of biological fluids have hitherto been limited to frozen or cold-storage types, which impedes the participation of laboratories in tropical or remote regions. Existing CRMs often do not fully meet user needs, particularly regarding storage stability and concentration relevance. Results. Using pooled Japanese human blood, we developed a freeze-dried, ambient-stable blood CRM, with certified values of 6.16 μg L−1 for total mercury (THg) and 5.46 μg L−1 for methylmercury (MeHg, as Hg). These concentrations are congruent with median exposure levels in fish-consuming populations (e.g., small island states and riverine Amazonian communities) derived from global biomonitoring data. Homogeneity, stability, and traceability were validated through inter-laboratory comparisons and rigorous uncertainty assessment. Significance. This ambient-stable blood CRM broadens global access to high-quality QA/QC of mercury speciation, especially in regions lacking cold-chain infrastructure. It contributes to capacity building under the Minamata Convention and strengthens interlaboratory comparability. Registration in COMAR and international collaborative deployment are under active development, enhancing the global infrastructure for mercury biomonitoring. |
|---|
| Keywords: | passive monitoring, methylmercury, blood samples, mercury detection, human biomonitoring, trace elements |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Submitted for review: | 04.12.2025 |
|---|
| Article acceptance date: | 23.04.2026 |
|---|
| Publication date: | 25.04.2026 |
|---|
| Publisher: | Elsevier |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | str. 1-11 |
|---|
| Numbering: | Vol. 1409, [article no.] 345580 |
|---|
| Source: | Nizozemska |
|---|
| PID: | 20.500.12556/DiRROS-29251  |
|---|
| UDC: | 543 |
|---|
| ISSN on article: | 1873-4324 |
|---|
| DOI: | 10.1016/j.aca.2026.345580 |
|---|
| COBISS.SI-ID: | 276799747 |
|---|
| Copyright: | © 2026 The Authors. |
|---|
| Note: | Nasl. z nasl. zaslona;
Soavtorice iz Slovenije: Milena Horvat, Ermira Begu, Polona Klemenčič, Adna Alilović;
Opis vira z dne 30. 4. 2026;
|
|---|
| Publication date in DiRROS: | 04.05.2026 |
|---|
| Views: | 38 |
|---|
| Downloads: | 20 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
