| Title: | Influence of particle size, shape, and magnetic properties on torque-driven biofilm removal using anisotropic magnetic particles |
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| Authors: | ID Pautu, Vincent (Author)
ID Marger, Laurine (Author)
ID Caf, Maja, Institut "Jožef Stefan" (Author)
ID Marger, Fabrice (Author)
ID Mekki, Mustapha (Author)
ID Kralj, Slavko, Institut "Jožef Stefan" (Author)
ID Milošević, Irena (Author) |
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| Files: |  URL - Source URL, visit https://pubs.rsc.org/en/Content/ArticleLanding/2026/NR/D6NR00046K
 PDF - Presentation file, download (1,40 MB)
MD5: 1EC86C26E60220A4613EAD092365B278
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Biofilms are structured communities of bacteria embedded within an extracellular polymeric substance (EPS) matrix, which forms a protective barrier that restricts drug penetration and increases antibiotic tolerance, making their complete elimination particularly challenging. Here, we investigate a magnetomechanical approach using rotating magnetic fields (RMFs) to deliver controlled mechanical stress to Enterococcus faecalis biofilms via anisotropic magnetic particles (AMPs). Microrods, nanochains, and nanorods with distinct sizes and magnetic properties were actuated under identical RMF conditions on implant-relevant titanium substrates. Micron-scale magnetic microrods generate sufficient magnetic torque to mechanically disrupt the EPS matrix and detach biofilm structures, significantly increasing suspended bacterial cells without marked bactericidal effects. In contrast, nanoscale AMPs do not induce biofilm detachment but cause membrane damage, increasing the proportion of injured cells. These findings demonstrate a size-dependent transition between microscale biofilm detachment and nanoscale membrane interactions, identifying particle size as the dominant parameter governing magneto-mechanical biofilm disruption. |
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| Keywords: | magnetomechanical biofilm disruption, anisotropic magnetic particles, nano–micro scale bacterial interactions |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 05.01.2026 |
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| Article acceptance date: | 26.03.2026 |
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| Publication date: | 27.03.2026 |
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| Publisher: | The Royal Society of Chemistry |
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| Year of publishing: | 2026 |
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| Number of pages: | str. [1-12] |
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| Numbering: | Vol. , iss. |
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| Source: | Združeno kraljestvo |
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| PID: | 20.500.12556/DiRROS-29223  |
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| UDC: | 620.3 |
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| ISSN on article: | 2040-3372 |
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| DOI: | 10.1039/D6NR00046K |
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| COBISS.SI-ID: | 276227075 |
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| Copyright: | This journal is © The Royal Society of Chemistry 2026 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorji: Laurine Marger, Maja Caf, Fabrice Marger, Mustapha Mekki, Slavko Kralj, Irena Milošević;
Opis vira z dne 23. 4. 2026;
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| Publication date in DiRROS: | 28.04.2026 |
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| Views: | 74 |
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| Downloads: | 34 |
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