| Title: | Venom-induced recurrent thrombocytopenia : a model of intervention-driven platelet modulation |
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| Authors: | ID Dobaja, Mojca (Author)
ID Reberšek, Katarina (Author)
ID Kurtović, Tihana (Author)
ID Leonardi, Adrijana (Author)
ID Križaj, Igor (Author)
ID Brvar, Miran (Author) |
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| Files: |  PDF - Presentation file, download (224,26 KB)
MD5: 6743AA541B42BFEAC2C9E2B3FDFE3EFD
 URL - Source URL, visit https://www.mdpi.com/2072-6651/17/12/605
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| Language: | English |
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| Typology: | 1.03 - Other scientific articles |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | We present the case of a Vipera ammodytes ammodytes (Vaa, nose-horned viper)-bitten patient with recurrent thrombocytopenia. A 53-year-old patient envenomated by Vaa experienced three episodes of venom-dependent thrombocytopenia (4, 57 and 11 × 109/L), all of which we managed with antivenom Fab fragments. Despite these three severe episodes of thrombocytopenia within 24 h, platelet function remained intact, as demonstrated by normal thromboelastometry and aggregometry (96, 126, and 150 U) results after antivenom was administered and the platelet count normalized. Furthermore, flow cytometry showed only 0.3–1.7% expression of P-selectin on platelets, indicating that platelets did not activate but remained functional during and after thrombocytopenia. We assessed platelet function using rotational thromboelastometry, which evaluates the overall kinetics of hemostasis, including clot formation and stability. We performed aggregometry, which also reflects platelet function, only when the platelet count was within the normal range. Flow cytometry quantified P-selectin expression as a key marker of platelet activation. This case demonstrates that a component of Vaa venom can repeatedly induce venom-dependent thrombocytopenia, which is reversible by intervention, while platelet function remains intact. |
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| Keywords: | Vipera ammodytes ammodytes, venom, thrombocytopenia, functional platelets, snaclec |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-7 |
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| Numbering: | Vol. 17, iss. 12, [Article no.] 605 |
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| PID: | 20.500.12556/DiRROS-29180  |
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| UDC: | 615.9 |
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| ISSN on article: | 2072-6651 |
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| DOI: | 10.3390/toxins17120605 |
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| COBISS.SI-ID: | 262844931 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 24. 12. 2025;
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| Publication date in DiRROS: | 23.04.2026 |
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| Views: | 100 |
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| Downloads: | 67 |
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