| Title: | Herpes simplex virus 1 encephalitis in first trimester of pregnancy : a case report |
|---|
| Authors: | ID Furlan, Matej (Author)
ID Lučovnik, Miha (Author)
ID Grasselli Kmet, Nina (Author) |
|---|
| Files: |  PDF - Presentation file, download (4,05 MB)
MD5: 0DDE80D23CA79B192FAEA069A87855E8
 URL - Source URL, visit https://onlinelibrary.wiley.com/doi/10.1155/crog/8743269
|
|---|
| Language: | English |
|---|
| Typology: | 1.03 - Other scientific articles |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Encephalitis caused by herpes simplex virus 1 (HSV-1) has been described in pregnancy, but it’s rare, with less than 20 cases being described in peer-reviewed literature. Physiologic changes in immune response during pregnancy influence the course of HSV-1 encephalitis (HSVE) and predispose pregnant women to severe complications. We present a case of herpetic encephalitis in a 12-weeks pregnant patient. In our patient neurologic condition deteriorated despite early diagnosis, appropriate antiviral and antiepileptic treatment, and suppurative neurocritical care, respectively. Disease progression stopped and the patient’s condition improved after pregnancy termination. Improvement could be a consequence of multiple factors, including delayed therapeutic effect of antiviral treatment, the impact of intensive care management, seizure control, and the possibility of spontaneous recovery as part of the natural disease course, respectively. This case highlights the potential severity of HSV-1 in early pregnancy and underscores the importance of multidisciplinary management and individualized decision-making in complex clinical situations. |
|---|
| Keywords: | herpes simplex virus, encephalitis, pregnancy |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | 4 str. |
|---|
| Numbering: | Vol. 2026, issue 1 |
|---|
| PID: | 20.500.12556/DiRROS-28917  |
|---|
| UDC: | 618.3 |
|---|
| ISSN on article: | 2090-6692 |
|---|
| DOI: | 10.1155/crog/8743269 |
|---|
| COBISS.SI-ID: | 275093251 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 4. 2026;
|
|---|
| Publication date in DiRROS: | 14.04.2026 |
|---|
| Views: | 99 |
|---|
| Downloads: | 78 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
