| Title: | CAR T therapy in adult DLBCL patients in Slovenia : evaluation of predictive scores for outcomes and adverse events |
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| Authors: | ID Sršen, Lucija (Author)
ID Auersperger, Irena (Author)
ID Janžič, Larisa (Author)
ID Kopitar, Andreja Nataša (Author)
ID Reberšek, Katarina (Author)
ID Jezeršek Novaković, Barbara (Author)
ID Novak, Polona (Author)
ID Rener, Karla (Author)
ID Šlajpah, Klara (Author)
ID Ihan, Alojz (Author)
ID Zver, Samo (Author)
ID Sever, Matjaž (Author) |
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| Files: |  PDF - Presentation file, download (6,40 MB)
MD5: 4C56CD2B9C3E090B355B49ABD11A56AC
 URL - Source URL, visit https://www.tandfonline.com/doi/full/10.1080/21645515.2026.2620889
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | CAR T cell therapy is a promising immunotherapy for hematologic malignancies, yet early prediction of outcomes and adverse events remains difficult, especially in small real-world cohorts. We retrospectively analyzed 14 adult patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR T cells in Slovenia, assessing IL-6 increase rates and established predictive metrics including EASIX-C, CAR-HEMATOTOX, and IBPS on Day -5 (pre-lymphodepletion) and Day 0 (infusion). Contrary to our expectation, an inverse correlation was observed between the increase rate of IL-6 and the occurrence of severe cytopenias, indicating higher IL-6 increase rate leads to less severe cytopenias. The EASIX-C score showed higher predictive values when calculated on Day 0, contrary to the CAR-HEMATOTOX score, whose higher predictive values were observed on Day -5. The IBPS predictive values showed mixed results when comparing Day -5 to Day 0. We observed 50% response rate and 29% remission rate. The results highlight the utility of predictive scores, with unexpected findings on IL-6 suggesting further study is necessary. |
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| Keywords: | CAR T cell therapy, adverse events, diffuse large B-cell lymphoma, hematologic malignancies |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-12 |
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| Numbering: | Vol. 22, no. 1 |
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| PID: | 20.500.12556/DiRROS-28795  |
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| UDC: | 616.1 |
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| ISSN on article: | 2164-5515 |
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| DOI: | 10.1080/21645515.2026.2620889 |
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| COBISS.SI-ID: | 267251459 |
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| Note: |
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| Publication date in DiRROS: | 07.04.2026 |
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| Views: | 40 |
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| Downloads: | 17 |
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