| Title: | The incidence of early recurrent venous thromboembolism : a systematic review and meta-analysis |
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| Authors: | ID Eischer, Lisbeth (Author)
ID Kyrle, Paul A. (Author)
ID Kaider, Alexandra (Author)
ID Schmidt, Anton (Author)
ID Wildner, Brigitte (Author)
ID Boc, Anja (Author), et al. |
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| Files: |  PDF - Presentation file, download (721,93 KB)
MD5: B1EEBE2C6C1D60E4AE7CF68110714389
 URL - Source URL, visit https://www.rpthjournal.org/article/S2475-0379(25)00641-7/fulltext
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Patients with venous thromboembolism (VTE) receive anticoagulation for at least 3 months. To evaluate recurrence risk thereafter, some strategies include D-dimer testing after discontinuing anticoagulation, which raises concern about early recurrence. Objectives: To assess the incidence of recurrent VTE within 30 days after stopping anticoagulation. Methods: We conducted a systematic review of EMBASE, CENTRAL, and MEDLINE to identify controlled trials and cohort studies of adult noncancer patients with deep vein thrombosis of the leg and/or pulmonary embolism treated with anticoagulants for ≥3 months. The primary outcome was symptomatic VTE within 30 days. The risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale. Pooled recurrence rates were calculated using fixed random-effects meta-analyses. Results: Of 42 studies, 24 (57%) provided data, encompassing 11,407 patients. Early recurrence occurred in 115 patients (1.01%), with a pooled incidence of 1.04% (95% CI, 0.8%-1.4%). Men had a risk similar to that of women (risk ratio, 1.2; 95% CI, 0.6-2.3; P = .7). Unprovoked VTE was associated with a 2.6-fold increase in risk (95% CI, 1.4-4.6; P < .001) compared with provoked VTE. Patients with deep vein thrombosis at presentation had a similar risk of recurrence compared with those with an incident pulmonary embolism (risk ratio, 0.6; 95% CI: 0.3-1.2; P = .1). Findings regarding age were inconsistent. None of the recurrences was fatal. The overall risk of bias was low. Conclusion: The incidence of early VTE recurrence after stopping anticoagulation is low. Temporarily discontinuing therapy to assess recurrence risk, therefore, appears safe and may aid in guiding treatment duration. |
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| Keywords: | anticoagulation, early recurrence, incidence, meta-analysis, venous thromboembolism |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-9 |
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| Numbering: | Vol. 9, iss. 1, [article no.] 103317 |
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| PID: | 20.500.12556/DiRROS-28737  |
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| UDC: | 616.1 |
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| ISSN on article: | 2475-0379 |
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| DOI: | 10.1016/j.rpth.2025.103317 |
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| COBISS.SI-ID: | 273221123 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 3. 2026;
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| Publication date in DiRROS: | 31.03.2026 |
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| Views: | 42 |
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| Downloads: | 16 |
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