| Title: | Integrating chronic inflammation and hypoxia : the potential role of HIF-1α in tumor behavior and therapy response in high-grade serous ovarian cancer |
|---|
| Authors: | ID Polajžer, Sara (Author)
ID Lukanović, David (Author)
ID Škof, Erik (Author)
ID Kobal, Borut (Author)
ID Černe, Katarina (Author)
ID Lakota, Katja (Editor) |
|---|
| Files: |  PDF - Presentation file, download (750,43 KB)
MD5: 1FDDDAE28717C862AE665B3E3823AF90
 URL - Source URL, visit https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1757708/full
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | High-grade serous ovarian carcinoma (HGSOC) is marked by late diagnosis and chemoresistance, partly driven by chronic inflammation and hypoxia in the tumor microenvironment. Hypoxia-inducible factor 1-alpha (HIF-1a) is a key regulator of these processes; however, its spatial distribution, interaction with inflammation, and effect on chemotherapy response in HGSOC remain unclear. This retrospective study included 28 advanced HGSOC patients treated with neoadjuvant chemotherapy (NACT). Samples were collected at primary surgery (PS) (ovarian and peritoneal tissue, plasma, ascites) and post-NACT at interval debulking surgery (IDS) (omentum, peritoneal tissue, plasma). HIF-1a mRNA expression varied by site, with higher levels in omental and peritoneal tissues compared to ovarian tissue. Plasma and ascites concentrations were significantly correlated, although the mean ascites concentration was lower. Elevated HIF-1a concentration in ascites and plasma at baseline correlated with ESR (erythrocyte sedimentation rate) >30 mm/h, which was also correlated with BRCA mutation status. No correlation was found between HIF-1a and CRP (C-reactive protein) levels. Higher HIF-1a concentrations in ascites and plasma were linked to poor chemotherapy response (CRS1) at IDS. No significant changes in plasma HIF-1a, ESR, or peritoneal HIF-1a mRNA expression were observed before and after chemotherapy. Increased peritoneal HIF-1a at baseline showed a trend toward shorter progression-free survival. These findings suggest that HIF-1a may reflect hypoxia-inflammation crosstalk associated with chemoresistance and progression in HGSOC. The hypoxic-inflammatory microenvironment appears to persist despite chemotherapy and could contribute to ongoing disease activity. However, these observations require validation in independent cohorts before any prognostic or predictive implications can be considered. |
|---|
| Keywords: | body fluids, chronic inflammation, HIF-1a, high-grade serous ovarian carcinoma, neoadjuvant chemotherapy, tumor tissue |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2026 |
|---|
| Number of pages: | str. 1-10 |
|---|
| Numbering: | Vol. 17, iss [article no.] 1757708 |
|---|
| PID: | 20.500.12556/DiRROS-28615  |
|---|
| UDC: | 616-097 |
|---|
| ISSN on article: | 1664-3224 |
|---|
| DOI: | 10.3389/fimmu.2026.1757708 |
|---|
| COBISS.SI-ID: | 271315203 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 3. 2026;
|
|---|
| Publication date in DiRROS: | 26.03.2026 |
|---|
| Views: | 165 |
|---|
| Downloads: | 99 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
