| Title: | IL-6 as an integrative biomarker of residual inflammation and visceral adiposity in psoriasis : a VAI threshold-dependent model |
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| Authors: | ID Merzel Šabović, Eva Klara (Author)
ID Kraner Šumenjak, Tadeja (Author)
ID Janić, Miodrag (Author) |
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| Files: |  PDF - Presentation file, download (894,00 KB)
MD5: 4C023B732BABD9C4177D9A73CB1A4060
 URL - Source URL, visit https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1699343/full
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Introduction: Psoriatic patients are frequently exposed to residual inflammation and visceral obesity, two factors that synergistically increase cardiometabolic risk. Methods: We evaluated IL-6 as a potential integrative biomarker linking these pathways in a cross-sectional study including 80 patients with well-controlled skin disease and 20 matched healthy controls. Serum IL-6 was measured by ELISA, and visceral adiposity estimated using the Visceral Adiposity Index (VAI). Results: Psoriatic patients displayed significantly higher IL-6 than controls (38.1 pg/mL [35.5–41.3] vs. 21.4 pg/mL [19.5–33.4]; p<0.001). A distinct VAI threshold of 1.3 was identified, above which IL-6 levels rose steeply until VAI 2.2 and then plateaued. Patients with VAI ≥1.3 had markedly higher IL-6 and pro-inflammatory cytokines than those below this cutoff. Random forest regression confirmed IFN-γ, IL-1β, IL-12p70, and IL-17 as dominant predictors of IL-6, while HbA1c, FIB-4, and treatment contributed minimally. Discussion: These findings suggest that IL-6 elevation in psoriasis primarily reflects cytokine-driven residual inflammation, with non-linear amplification once visceral adiposity exceeds a critical threshold. The threshold-dependent IL-6 dynamic highlights a clinically meaningful inflection point, integrating residual inflammation and visceral fat dysfunction, and may guide early cardiometabolic risk stratification and intervention. Prospective validation is warranted. |
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| Keywords: | interleukin-6, psoriasis, visceral adiposity index, systemic inflammation, obesity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-7 |
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| Numbering: | Vol. 16, article no. ǂ1699343 |
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| PID: | 20.500.12556/DiRROS-28504  |
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| UDC: | 61 |
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| ISSN on article: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1699343 |
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| COBISS.SI-ID: | 262509827 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 22. 12. 2025;
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| Publication date in DiRROS: | 23.03.2026 |
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| Views: | 159 |
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| Downloads: | 107 |
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