| Title: | Adipose tissue transcriptome profiles of local Krškopolje pig and modern hybrid pigs receving reduced protein diets: : expression profiling by high throughput sequencing |
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| Authors: | ID Poklukar Žnidaršič, Klavdija (Author)
ID Škrlep, Martin (Author)
ID Čandek-Potokar, Marjeta (Author) |
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| Files: |  URL - Source URL, visit https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309090
Description: Podatki nedostopni, 7. 10. 2025, dostopni po 24. 9. 2029
 PDF - Presentation file. (481,38 KB, This file will be accessible after 24.09.2029)
MD5: 49DF1579FA25210FE0E9DCF2986A2DCD
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| Language: | English |
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| Typology: | 2.20 - Complete scientific database of research data |
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| Organization: |  KIS - Agricultural Institute of Slovenia
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| Abstract: | The main objective of this study was to investigate transcriptomic differences in subcutaneous adipose tissue between the local Krškopolje pig and modern hybrids, and to assess the effects of a reduced-protein diet in both genotypes. Comparative analysis between Krškopolje pigs and modern crossbreeds revealed 375 differentially expressed genes, with 189 upregulated and 186 downregulated in Krškopolje pigs. The upregulated genes were enriched in processes related to adipogenesis (SLC7A10, ADIRF, INHBB, SFRP2), extracellular matrix remodeling (COL6A5, COL4A5, COL2A1), calcium signaling (TRPV4, CAMK2A, CALML5), pro-inflammatory cytokines (IL1A, TNFSF9, CXCL8, PTGS2), and cholesterol metabolism (CYP1A1, CYP2A19, CES1). In contrast, the reduced-protein diet induced only minor transcriptional changes at the individual gene level in both Krškopolje pigs and modern crossbreeds. |
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| Keywords: | RNA sequences, pigs, adipose tissue, high throughput sequencing, RNA, transcriptome profiles, gene expression, locel breeds, hybrid breeds, data, data set |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 24.09.2025 |
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| Place of publishing: | Bethesda |
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| Place of performance: | Bethesda |
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| Publisher: | Gene Expression Omnibus (GEO) |
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| Year of publishing: | 2025 |
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| Year of performance: | 2025 |
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| Number of pages: | 1 spletni vir |
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| PID: | 20.500.12556/DiRROS-28462  |
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| UDC: | 636 |
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| COBISS.SI-ID: | 252017667 |
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| Note: | Nasl. z. nasl. zaslona;
Opis vira z dne 7. 10. 2025;
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| Publication date in DiRROS: | 20.03.2026 |
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| Views: | 255 |
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| Downloads: | 47 |
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| Metadata: |    |
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