| Title: | Serum vitamin D and inflammatory markers in SARS-CoV-2 positive pregnant women |
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| Authors: | ID Mesarič, Vita Andreja (Author)
ID Premru-Sršen, Tanja (Author)
ID Kavšek, Gorazd (Author)
ID Verdenik, Ivan (Author)
ID Štrukelj, Aleksandra (Author)
ID Druškovič, Mirjam (Author) |
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| Files: |  PDF - Presentation file, download (276,86 KB)
MD5: 342EA026C33685050347B6593AA1F2D9
 URL - Source URL, visit https://www.degruyterbrill.com/document/doi/10.1515/jpm-2025-0356/html
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Objectives: The SARS-CoV-2 pandemic was declared by World Health Organisation (WHO) in March 2020, causing health and economic disruptions and millions of deaths. Pregnant women represent a vulnerable group, as COVID-19 during pregnancy increases the risk of preterm birth, preeclampsia, and severe maternal illness. Nutritional status, such as vitamin D deficiency, may influence these outcomes, yet data on its status in the cohort of SARS-CoV-2 positive pregnant women as well as its association with inflammatory and angiogenic markers is scarce. The aim of this study was to evaluate the levels of vitamin D in the cohort of SARSCoV- 2 positive pregnant women and its association with inflammatory and angiogenic markers. Methods: Prospective cohort study at Ljubljana Maternity Hospital (Oct 1, 2020–Mar 30, 2021) enrolled singleton pregnancies with PCR-confirmed SARS-CoV-2 within the last 14 days, delivering at our institution. Results: Among 235 SARS-CoV-2-positive pregnant women 62.1% had adequate and 21.3% insufficient level of vitamin D and 13.6%were vitaminDdeficient. Statistical analysis revealed no significant correlations between 25-OH-vitamin D and Creactive protein (CRP), procalcitonin (PCT), leukocyte count, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), the sFlt-1/PlGF ratio, or body mass index (BMI). Conclusions: Our prospective cohort study revealed that high proportion of pregnant women has inadequate levels of vitamin D. Although maternal insufficiency is linked to adverse outcomes, its association with inflammatory and angiogenic markers remains unclear. Rigorous studies in pregnancy are essential to clarify vitamin D’s role in COVID-19 complications in pregnancy. |
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| Keywords: | COVID-19, pandemic, pregnancy, SARS-CoV-2, vitamin D deficiency, inflammation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 183-188 |
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| Numbering: | Vol. 54, issue 1 |
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| PID: | 20.500.12556/DiRROS-28433  |
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| UDC: | 618.2/.7 |
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| ISSN on article: | 1619-3997 |
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| DOI: | 10.1515/jpm-2025-0356 |
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| COBISS.SI-ID: | 259554307 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 2. 12. 2025;
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| Publication date in DiRROS: | 19.03.2026 |
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| Views: | 107 |
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| Downloads: | 74 |
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