| Title: | Hemodynamic performance of a self-expanding transcatheter aortic valve with an intra-annular leaflet position in patients with a small aortic annulus |
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| Authors: | ID Bunc, Matjaž (Author)
ID Verček, Gregor (Author)
ID De Backer, Ole (Author) |
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| Files: |  PDF - Presentation file, download (518,13 KB)
MD5: E9118C8103DA4268FFC223407DE3FC72
 URL - Source URL, visit https://doi.org/10.3390/medicina61040661
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background and Objectives: Transcatheter aortic valve implantation is associated with a higher risk for elevated trans-prosthetic gradients and prosthesis-patient mismatch in patients with a small aortic annulus. We aimed to assess the short-term hemodynamic performance of self-expanding transcatheter aortic valves with an intra-annular leaflet position in patients with small aortic anatomies. Materials and Methods: Consecutive patients with small aortic annuli (annular area < 430 mm2), who underwent transcatheter aortic valve implantation with a self-expanding Portico or Navitor (Abbott Medical, St. Paul, MN, USA) transcatheter aortic valve between October 2017 and August 2024 at the University Medical Centre Ljubljana, Slovenia, were analyzed. The main endpoints were the post-procedural mean trans-prosthetic gradient, the presence of moderate or severe prosthesis-patient mismatch or paravalvular regurgitation. Results: Overall, 37 patients were included in the study (29 patients with a native aortic valve and 8 patients undergoing valve-in-valve transcatheter aortic valve implantation). The mean age was 81.6 ± 4.3 years, 32 patients (86.5%) were female. The median annular perimeter was 70.8 mm (interquartile range 67.3–74.1 mm) and the median annular area was 379 mm2 (interquartile range 355–412 mm2). The post-procedural mean trans-prosthetic gradient was 9.0 ± 3.5 mmHg, with no cases with a mean gradient > 20 mmHg. Moderate and severe prosthesis-patient mismatch was observed in 21.2% and 3.0% of patients, respectively. Mild paravalvular regurgitation was noted in 44.1% of patients, there were no cases of moderate or severe paravalvular regurgitation. One patient (3.0%) had moderate valvular regurgitation. Conclusions: Self-expanding transcatheter aortic valves with an intra-annular leaflet position are associated with favorable hemodynamic performance in patients with a small aortic annulus. |
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| Keywords: | transcatheter aortic valve implantation, TAVI, TAVR, small aortic annulus, self-expanding, intra-annular, transcatheter aortic valve |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-8 |
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| Numbering: | Vol. 61, issue 4, [article no.] 661 |
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| PID: | 20.500.12556/DiRROS-28104  |
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| UDC: | 616.1 |
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| ISSN on article: | 1648-9144 |
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| DOI: | 10.3390/medicina61040661 |
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| COBISS.SI-ID: | 240510211 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 6. 2025;
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| Publication date in DiRROS: | 10.03.2026 |
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| Views: | 67 |
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| Downloads: | 54 |
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