| Title: | CCR5 Δ32 and CTLA-4 +49 A/G gene polymorphisms and interferon-β treatment response in Croatian and Slovenian multiple sclerosis patients |
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| Authors: | ID Nekić, Jasna (Author)
ID Stanković Matić, Ivana (Author)
ID Rački, Valentino (Author)
ID Janko Labinac, Dolores (Author)
ID Vuletić, Vladimira (Author)
ID Kapović, Miljenko (Author)
ID Ristić, Smiljana (Author)
ID Peterlin, Borut (Author)
ID Starčević-Čizmarević, Nada (Author) |
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| Files: |  PDF - Presentation file, download (271,56 KB)
MD5: 6EEF687C14AC351D146B8D5DCBEC461A
 URL - Source URL, visit https://doi.org/10.3390/ijms25137412
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | The aim of the present study was to investigate the impact of CCR5 Δ32 and CTLA-4 polymorphisms on the response to IFN-β treatment in our cohort of MS patients from Croatia and Slovenia. Genomic DNA was obtained from 295 MS patients (230 female; 65 male) classified as responders (n = 173) and non-responders (n = 122) based on clinical criteria for treatment efficacy. Genotyping was performed via PCR/PCR-RFLP. No significant differences in the genotype/allele frequencies of CCR5Δ32 and CTLA-4 +49 A/G were detected between male responders and nonresponders. A significantly higher prevalence (p = 0.039) of the CTLA-4 +49 AA genotype was found in female responders (42.1%) compared to non-responders (28.9%). Using multiple forward regression analysis, the CTLA-4 +49 AA genotype significantly predicted a positive response to IFN-β therapy in females (p = 0.011) and contributed to 4.5% of response variability. Furthermore, the combined presence of the CCR5Δ32 wtwt/CTLA-4 +49 AA genotype significantly predicted a positive response to treatment in females (p = 0.025). The age at disease onset, pretreatment relapse rate, and baseline EDSS score were not reliable predictors of treatment response in MS patients. Our results indicate that the presence of the CCR5Δ32 polymorphism was not associated with the response to IFN-β treatment, whereas the CTLA-4 +49 polymorphism showed a positive correlation with an optimal response in female patients. |
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| Keywords: | multiple sclerosis, polymorphism, treatment response, interferon-β |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-11 |
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| Numbering: | Vol. 25, iss. 13, [article no.] 7412 |
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| PID: | 20.500.12556/DiRROS-28094  |
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| UDC: | 616.8 |
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| ISSN on article: | 1422-0067 |
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| DOI: | 10.3390/ijms25137412 |
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| COBISS.SI-ID: | 239992835 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 6. 2025;
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| Publication date in DiRROS: | 10.03.2026 |
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| Views: | 37 |
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| Downloads: | 19 |
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