| Title: | Factors associated with decision to treat or not to treat Helicobacter pylori infection in children : data from the EuroPedHp Registry |
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| Authors: | ID Le Thi, Thu Giang (Author)
ID Werkstetter, Katharina (Author)
ID Kotilea, Kallirroi (Author)
ID Bontems, Patrick (Author)
ID Cabral, José (Author)
ID Cilleruelo Pascual, Maria Luz (Author)
ID Homan, Matjaž (Author), et al. |
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| Files: |  PDF - Presentation file, download (413,59 KB)
MD5: CD8FC9970C5F423082BDD186C9ACCFDE
 URL - Source URL, visit https://doi.org/10.1111/hel.13134
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: European and North-American guidelines on management of H. pylori infection in children provide the option not to treat even if the infection is endoscopically confirmed. We used data from the EuroPedHp Registry to identify factors associated with therapy decisions. Methods: We included treatment-naïve patients reported between 2017 and 2020 from 30 centers in 17 European countries. Multivariable logistic regression identified factors including comorbidities within and outside the gastrointestinal (GI) tract influencing the decision for or against therapy. Results: Of 1165 patients (52% females, median age 12.8), 28% (321/1165) reported any alarm symptom, 26% (307/1165) comorbidities, and 16% (192/1165) did not receive eradication treatment. Therapy was initiated less often in children having any GI comorbidity (57%, n = 181), particularly in those with eosinophilic esophagitis (60%, n = 35), inflammatory bowel disease (54%, n = 28), and celiac disease (43%, n = 58), compared to those with non-GI (86%, n = 126) or no comorbidity (89%, n = 858), despite similar frequencies of alarm and non-alarm symptoms, ulcers, erosions, and nodular gastritis. Patients with GI and without comorbidities remained more likely untreated in high versus low H. pylori prevalence countries (p < 0.0001). In children without comorbidities, factors favoring therapy included older age, being overweight, having symptoms, erosions, antral nodularity, and available antibiotic susceptibility results. Conclusion: In this cohort, H. pylori-infected children with GI comorbidities compared to no comorbidity showed 75% reduced chance of receiving eradication therapy. We found no evidence supporting different management strategies in infected patients with GI comorbidities compared to all pediatric patients with endoscopically proven H. pylori infection. |
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| Keywords: | children, comorbidities, celiac disease, Helicobacter pylori |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-18 |
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| Numbering: | Vol. 29, iss. 5, [article no.] e13134 |
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| PID: | 20.500.12556/DiRROS-28062  |
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| UDC: | 616.3 |
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| ISSN on article: | 1523-5378 |
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| DOI: | 10.1111/hel.13134 |
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| COBISS.SI-ID: | 237893123 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 2. 6. 2025;
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| Publication date in DiRROS: | 09.03.2026 |
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| Views: | 202 |
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| Downloads: | 170 |
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