| Title: | Prevalence of chronic HCV infection in EU/EEA countries in 2019 using multiparameter evidence synthesis |
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| Authors: | ID Thomadakis, Christos (Author)
ID Gountas, lias (Author)
ID Duffell, Erika (Author)
ID Gountas, Konstantinos (Author)
ID Bluemel, Benjamin (Author)
ID Seyler, Thomas (Author)
ID Pericoli, Filippo Maria (Author)
ID Kászoni-Rückerl, Irene (Author)
ID El-Khatib, Ziad (Author)
ID Matičič, Mojca (Author), et al. |
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| Files: |  PDF - Presentation file, download (991,98 KB)
MD5: D18E089FAF5604772A2F83B1D32CE17A
 URL - Source URL, visit https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(23)00211-9/fulltext
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background Epidemiological data are crucial to monitoring progress towards the 2030 Hepatitis C Virus (HCV) elimination targets. Our aim was to estimate the prevalence of chronic HCV infection (cHCV) in the European Union (EU)/European Economic Area (EEA) countries in 2019. Methods Multi-parameter evidence synthesis (MPES) was used to produce national estimates of cHCV defined as: π = πrecρrec + πexρex + πnonρnon; πrec, πex, and πnon represent cHCV prevalence among recent people who inject drugs (PWID), ex-PWID, and non-PWID, respectively, while ρrec, ρex, and ρnon represent the proportions of these groups in the population. Information sources included the European Centre for Disease Prevention and Control (ECDC) national operational contact points (NCPs) and prevalence database, the European Monitoring Centre for Drugs and Drug Addiction databases, and the published literature. Findings The cHCV prevalence in 29 of 30 EU/EEA countries in 2019 was 0.50% [95% Credible Interval (CrI): 0.46%, 0.55%]. The highest cHCV prevalence was observed in the eastern EU/EEA (0.88%; 95% CrI: 0.81%, 0.94%). At least 35.76% (95% CrI: 33.07%, 38.60%) of the overall cHCV prevalence in EU/EEA countries was associated with injecting drugs. Interpretation Using MPES and collaborating with ECDC NCPs, we estimated the prevalence of cHCV in the EU/EEA to be low. Some areas experience higher cHCV prevalence while a third of prevalent cHCV infections was attributed to PWID. Further efforts are needed to scale up prevention measures and the diagnosis and treatment of infected individuals, especially in the east of the EU/EEA and among PWID. |
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| Keywords: | HCV, hepatitis C, chronic hepatitis, prevalence, elimination, Europe |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | 12 str. |
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| Numbering: | [article no.] ǂ100792, Vol. 36 |
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| PID: | 20.500.12556/DiRROS-27919  |
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| UDC: | 616.9 |
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| ISSN on article: | 2666-7762 |
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| DOI: | 10.1016/j.lanepe.2023.100792 |
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| COBISS.SI-ID: | 236378883 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 19. 5. 2025;
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| Publication date in DiRROS: | 27.02.2026 |
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| Views: | 136 |
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| Downloads: | 51 |
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