| Title: | Biomaterials augmented with filtered bone marrow aspirate for the treatment of talar osteochondral lesions : a comparison of clinical and cellular parameters |
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| Authors: | ID Kolar, Matic (Author)
ID Veber, Matija (Author)
ID Girandon, Lenart (Author)
ID Drobnič, Matej (Author) |
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| Files: |  PDF - Presentation file, download (561,22 KB)
MD5: AB4325E30B44062FBEBD859DAB54CEBF
 URL - Source URL, visit https://journals.sagepub.com/doi/10.1177/10225536231219970
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Biomaterials augmented with Bone Marrow Aspirate Concentrate (BMAC) are becoming increasingly utilized in the cartilage treatment. However, the potential role of cellular parameters in the intraoperatively applied BMAC have yet to be elucidated. Purpose: (A) To evaluate clinical outcomes and safety of a combined single-step approach with scaffolds (fibrin glues, collagen gels, collagen-hydroxyapatite membrane) and filtered Bone Marrow Aspirate (fBMA) for the treatment of osteochondral lesions of the talus (OLTs). (B) To identify significant factors for postoperative improvements, considering cellular parameters as potential predictors. Methods: All the patients operated on due to OLTs by the combination above were selected from the hospital registry database (35 pts, years 16-55, and minimally 1 year follow-up). Treatment outcomes were followed clinically with Patient-reported outcome measures (PROMs), and by pursuing serious adverse events (SAE) and graft failures (GF). Cellular parameters of the injected fBMA were determined. Pre- and postoperative PROMs values were compared to evaluate postoperative improvements. Multivariable regression models were applied to identify potential factors (demographics, medical history, joint and lesion characteristics, scaffold type, surgical and cellular parameters) that predict the treatment outcomes. Results: At the mean follow-up of 32.2 (12.5) months, all Foot and Ankle Outcome Score (FAOS) and European Quality of Life in Five Dimensions Three-Level (EQ-5D-3 L) values improved significantly. 4 (11%) SAE (3 arthrofibrosis, one hardware removal), and 3 (9%) GF occurred. Female gender and concomitant procedures were the main negative predictors for postoperative outcomes. The number of fibroblast colony forming units (CFU-F) or their proportion among total nucleated cells (CFU-F/TNC) were positively correlated with the improvements of some PROMs. Conclusions: Scaffolds augmented with fBMA proved as an adequate and safe approach for OLTs treatment. Cellular parameters seem to influence the treatment outcomes, thus further attention should be given to the intraoperatively applied products. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | 9 str. |
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| Numbering: | Vol. 32, issue 1 |
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| PID: | 20.500.12556/DiRROS-27915  |
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| UDC: | 61 |
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| ISSN on article: | 2309-4990 |
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| DOI: | 10.1177/10225536231219970 |
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| COBISS.SI-ID: | 236067331 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 15. 5. 2025;
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| Publication date in DiRROS: | 27.02.2026 |
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| Views: | 113 |
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| Downloads: | 53 |
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