| Title: | Advancing allogeneic hematopoietic stem cell transplantation outcomes through immunotherapy : a comprehensive review of optimizing non-CAR donor T-lymphocyte infusion strategies |
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| Authors: | ID Braidotti, Stefania (Author)
ID Granzotto, Marilena (Author)
ID Curci, Debora (Author)
ID Faganel Kotnik, Barbara (Author)
ID Maximova, Natalia (Author) |
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| Files: |  PDF - Presentation file, download (329,61 KB)
MD5: C731806337BA5C30562FA4349AB37788
 URL - Source URL, visit https://www.mdpi.com/2227-9059/12/8/1853
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Optimized use of prophylactic or therapeutic donor lymphocyte infusions (DLI) is aimed at improving clinical outcomes in patients with malignant and non-malignant hematological diseases who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Memory Tlymphocytes (CD45RA−/CD45RO+) play a crucial role in immune reconstitution post-HSCT. The infusion of memory T cells is proven to be safe and effective in improving outcomes due to the enhanced reconstitution of immunity and increased protection against viremia, without exacerbating graft-versus-host disease (GVHD) risks. Studies indicate their persistence and efficacy in combating viral pathogens, suggesting a viable therapeutic avenue for patients. Conversely, using virus-specific T cells for viremia control presents challenges, such as regulatory hurdles, cost, and production time compared to CD45RA-memory T lymphocytes. Additionally, the modulation of regulatory T cells (Tregs) for therapeutic use has become an important area of investigation in GVHD, playing a pivotal role in immune tolerance modulation, potentially mitigating GVHD and reducing pharmacological immunosuppression requirements. Finally, donor T cell-mediated graft-versus-leukemia immune responses hold promise in curbing relapse rates post-HSCT, providing a multifaceted approach to therapeutic intervention in high-risk disease scenarios. This comprehensive review underscores the multifaceted roles of T lymphocytes in HSCT outcomes and identifies avenues for further research and clinical application |
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| Keywords: | hematopoietic stem cell transplantation, T lymphocyte, memory T cells, virus-specific T cells, graft-versus-host disease, graft-versus-leukemia |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-19 |
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| Numbering: | Vol. 12, iss. 8, [article no.] 1853 |
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| PID: | 20.500.12556/DiRROS-27873  |
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| UDC: | 61 |
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| ISSN on article: | 2227-9059 |
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| DOI: | 10.3390/biomedicines12081853 |
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| COBISS.SI-ID: | 229915139 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 3. 2025;
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| Publication date in DiRROS: | 26.02.2026 |
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| Views: | 153 |
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| Downloads: | 56 |
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