| Title: | Long-term IGF-1 maintenance in the upper-normal range has beneficial effect on low-grade inflammation marker in adults with growth hormone deficiency |
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| Authors: | ID Klinc, Ana (Author)
ID Janež, Andrej (Author)
ID Jensterle Sever, Mojca (Author) |
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| Files: |  PDF - Presentation file, download (640,67 KB)
MD5: B866A4E1E55CD54742F662241E45626D
 URL - Source URL, visit https://www.mdpi.com/1422-0067/26/5/2010
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | The distinctive effects of maintaining the upper- (0–2) versus lower-normal (−2–0) range of IGF-1 SDS in adult growth hormone deficiency (AGHD) remain understudied. We conducted a cross-sectional study on 31 patients with AGHD receiving growth hormone replacement therapy (GHRT) with daily GH for >5 years, with a 2-year mean IGF-1 SDS ranging between −2 and +2. Patients were categorized into the upper- or lower-normal range IGF-1 SDS groups according to their 2-year mean. Associations of clinical characteristics, anthropometric parameters, laboratory tests, and vascular markers of subclinical atherosclerosis with the 2-year IGF-1 SDS range and 5-year mean IGF-1 SDS were explored. Long-term maintenance of upper-normal IGF-1 SDSs was more common in men and in patients with a longer duration of GHRT. Patients with tumor-related AGHD had a lower 5-year mean IGF-1 SDS. Long-term maintenance of IGF-1 SDS in the upper-normal range was associated with lower high-sensitivity C-reactive protein (hs-CRP) levels (median (25–75% range): 0.8 (0.6–1.1) vs. 1.8 (0.8–4.6); p = 0.005). Moreover, a negative correlation was identified between a hs-CRP and the 5-year mean IGF-1 SDS. The association between the upper-normal IGF-1 SDS range and lower body fat percentage lost significance after adjusting for sex, due to the higher proportion of male patients in the upper-normal IGF-1 SDS group. In conclusion, long-term maintenance of upper-normal IGF-1 SDSs was associated with male sex and reduced low-grade inflammation. Randomized controlled studies are needed to evaluate the long-term and sex-specific effects of targeting the upper- vs. lower-normal IGF-1 range in AGHD. |
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| Keywords: | adult growth hormone deficiency, growth hormone replacement therapy, IGF-1 range |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Vol. 26, iss. 5, [article no.] 2010 |
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| PID: | 20.500.12556/DiRROS-27839  |
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| UDC: | 616.4 |
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| ISSN on article: | 1422-0067 |
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| DOI: | 10.3390/ijms26052010 |
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| COBISS.SI-ID: | 227344899 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 30. 9. 2024;
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| Publication date in DiRROS: | 26.02.2026 |
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| Views: | 223 |
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| Downloads: | 120 |
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