| Title: | Idarucizumab reversal in subdural hemorrhage : a single-center experience |
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| Authors: | ID Mrvar Brečko, Anita (Author)
ID Simerl Jožef, Monika (Author)
ID Trebše, Ana (Author)
ID Zupan, Matija (Author)
ID Velnar, Tomaž (Author)
ID Frol, Senta (Author) |
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| Files: |  PDF - Presentation file, download (509,55 KB)
MD5: 6B8BCE2F0F5EB9849F8BA17D8D68F004
 URL - Source URL, visit https://doi.org/10.3390/life15101617
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Prompt reversal of anticoagulation in the elderly population with subdural hematoma (SDH) is critical to reduce morbidity and facilitate timely surgical intervention. In patients receiving dabigatran, idarucizumab provides rapid anticoagulation reversal. We evaluated clinical and radiological outcomes of dabigatran-treated SDH patients receiving idarucizumab, including those undergoing surgical management. We conducted a single-center retrospective observational study of dabigatran-treated patients who received idarucizumab reversal for traumatic or spontaneous SDH between 2016 and 2024. Hematoma evolution was monitored using follow-up computed tomography. Clinical and neurological outcomes were recorded. Of eleven included patients (mean age 80.8 ± 6.7 years; 36% female), falls were the primary cause (64%). SDH was chronic in 64% and acute in 36%, with associated traumatic lesions in 33%. Surgical evacuation was performed in 82% of cases. Anticoagulation was resumed in 27% of patients within 3–4 weeks post-discharge. The median Glasgow Outcome Scale Extended (GOSE) score was 5, indicating moderate disability. In-hospital mortality was 9.1%. Idarucizumab enabled rapid and safe dabigatran reversal in this high-risk elderly cohort, supporting both surgical and conservative SDH management. Functional outcomes were moderate and mortality was low, underscoring its clinical utility. Targeted reversal strategies remain essential, and further research should refine long-term anticoagulation management. |
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| Keywords: | subdural hematoma, idarucizumab, dabigatran, anticoagulation reversal, case series |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-12 |
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| Numbering: | Vol. 15, iss. 10, [article no.] 1617 |
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| PID: | 20.500.12556/DiRROS-27775  |
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| UDC: | 616.8 |
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| ISSN on article: | 2075-1729 |
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| DOI: | 10.3390/life15101617 |
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| COBISS.SI-ID: | 253800451 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 20. 10. 2025;
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| Publication date in DiRROS: | 24.02.2026 |
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| Views: | 44 |
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| Downloads: | 18 |
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