| Title: | Prognostic factors and survival outcomes of first CNS relapse in childhood acute lymphoblastic leukemia : results from the ALL-IC REL 2016 study |
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| Authors: | ID Hazar, Volkan (Author)
ID Makiya, Monika (Author)
ID Yalçın, Koray (Author)
ID Tadecilla Cadiu, Juan (Author)
ID Manni, Federico (Author)
ID Reyes Barragan, Andrea (Author)
ID Kavčič, Marko (Author)
ID Prelog, Tomaž (Author)
ID Jazbec, Janez (Author), et al. |
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| Files: |  PDF - Presentation file, download (2,43 MB)
MD5: B7FB139CC81324B8EB85CF1341B61168
 URL - Source URL, visit https://www.tandfonline.com/doi/full/10.1080/10428194.2025.2598861
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Acute lymphoblastic leukemia (ALL) is among the most curable pediatric cancers, yet relapse involving the central nervous system (CNS) remains a major therapeutic obstacle. In this prospective cohort, 97 children (aged 1.1–18.2 years) experiencing their first CNS relapse were enrolled in the ALL-IC REL study. Relapses were classified as isolated CNS (i-CNS, n = 43) or combined CNS (c-CNS, n = 54), and patients received treatment through standard- or high-risk regimens, encompassing chemotherapy, cranial irradiation, and allogeneic stem cell transplantation. The estimated 2-year event-free survival was 40.0%, and overall survival 49.4%, closely matching outcomes reported internationally. Survival rates were comparable across i-CNS and c-CNS relapses, while induction failure occurred more frequently in c-CNS. Multivariable analysis identified female sex, T-cell phenotype, and very early relapse as independent predictors of poor prognosis. These results underscore the critical necessity for risk-adapted therapy techniques and the incorporation of innovative medicines into forthcoming procedures. |
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| Keywords: | childhood, acute lymphoblastic leukemia, central nervous system relapse, prognostic factors, survival, hematopoietic stem cell transplantation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 416-423 |
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| Numbering: | Vol. 67, no. 2 |
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| PID: | 20.500.12556/DiRROS-27745  |
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| UDC: | 616-053.2 |
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| ISSN on article: | 1029-2403 |
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| DOI: | 10.1080/10428194.2025.2598861 |
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| COBISS.SI-ID: | 263367683 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 5. 1. 2026;
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| Publication date in DiRROS: | 24.02.2026 |
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| Views: | 195 |
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| Downloads: | 59 |
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