| Title: | Invasive aspergillosis in liver transplant recipients in the current era |
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| Authors: | ID Kimura, Muneyoshi (Author)
ID Rinaldi, Matteo (Author)
ID Kothari, Sagar (Author)
ID Giannella, Maddalena (Author)
ID Anjan, Shweta (Author)
ID Rojko, Tereza (Author)
ID Ribnikar, Marija (Author), et al. |
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| Files: |  PDF - Presentation file, download (594,36 KB)
MD5: 7A3FF35F061A2F42BB9E04593704C8E3
 URL - Source URL, visit https://doi.org/10.1016/j.ajt.2024.05.016
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Invasive aspergillosis (IA) is a rare but fatal disease among liver transplant recipients (LiTRs). We performed a multicenter 1:2 case-control study comparing LiTRs diagnosed with proven/probable IA and controls with no invasive fungal infection. We included 62 IA cases and 124 matched controls. Disseminated infection occurred only in 8 cases (13%). Twelve-week all-cause mortality of IA was 37%. In multivariate analyses, systemic antibiotic usage (adjusted odds ratio [aOR], 4.74; P ¼.03) and history of pneumonia (aOR, 48.7; P ¼ .01) were identified as independent risk factors associated with the occurrence of IA. Moreover, reoperation (aOR, 5.99; P ¼.01), systemic antibiotic usage (aOR, 5.03; P ¼.04), and antimold prophylaxis (aOR, 11.9; P ¼.02) were identified as independent risk factors associated with the occurrence of early IA. Among IA cases, Aspergillus colonization (adjusted hazard ratio [aHR], 86.9; P <.001), intensive care unit stay (aHR, 3.67; P ¼.02), disseminated IA (aHR, 8.98; P <.001), and dialysis (aHR, 2.93; P ¼.001) were identified as independent risk factors associated with 12-week all-cause mortality, while recent receipt of tacrolimus (aHR, 0.11; P ¼ .001) was protective. Mortality among LiTRs with IA remains high in the current era. The identified risk factors and protective factors may be useful for establishing robust targeted antimold prophylactic and appropriate treatment strategies against IA. |
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| Keywords: | invasive aspergillosis, liver transplantation, targeted antifungal prophylaxis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 2092-2107 |
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| Numbering: | Vol. 24, iss. 11 |
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| PID: | 20.500.12556/DiRROS-27726  |
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| UDC: | 616.36 |
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| ISSN on article: | 1600-6143 |
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| DOI: | 10.1016/j.ajt.2024.05.016 |
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| COBISS.SI-ID: | 244640515 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 1. 8. 2025;
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| Publication date in DiRROS: | 23.02.2026 |
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| Views: | 175 |
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| Downloads: | 53 |
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