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Title: Z zdravili povzročena poškodba pljučnega intersticija Authors: ID Morgan, Tina (Author) Files: PDF - Presentation file, download (172,91 KB) MD5: 0E11B259E1E8D6556708B97D227BE863   Language: Slovenian Typology: 1.02 - Review Article Organization: SFD - Slovenian Pharmaceutical Society Abstract: Z zdravili povzročena prizadetost pljučnega intersticija je redek neželen učinek zdravil in predstavlja 3–5 % intersticijske pljučne patologije. Več kot 400 zdravil so povezali s tem neželenim učinkom, med njimi pa so najpogostejši antirevmatiki, onkološka zdravila in antiaritmiki. Klinična slika lahko zajema vse od asimptomatske bolezni do življenje ogrožajoče dihalne odpovedi. V zgodnjih vnetnih fazah bolezni so spremembe reverzibilne ob odtegnitvi povzročitelja ali s protivnetnim zdravljenjem. Napredovanje vnetja pa lahko vodi v fibrozo, ki je lahko progresivna. Dejavniki tveganja so starost, kajenje, znana intersticijska pljučna bolezen in obsevanje prsnega koša. Diagnosticiranje je zelo kompleksno in zajema izključitev infekcijskih vzrokov in z osnovno boleznijo povezane patologije. Zdravljenje temelji na odtegnitvi domnevnega povzročitelja, ob hujšem poteku pa tudi dolgotrajni uporabi sistemskih glukokortikoidov. V zadnjih letih so pogostejši vzrok za pljučne prizadetosti zaviralci imunskih nadzornih točk, ki predvsem pri pljučnem raku povzročajo pnevmonitis pogosteje kot druga zdravila. Keywords: intersticijska prizadetost pljuč, neželeni učinki, zdravila Publication status: Published Publication version: Version of Record Publication date: 01.10.2025 Year of publishing: 2025 Number of pages: str. 237-245 Numbering: Letn. 76, št. 4 PID: 20.500.12556/DiRROS-27593  UDC: 616.24:615.017 ISSN on article: 0014-8229 COBISS.SI-ID: 254093571  Note: Besedilo v slov.; Publication date in DiRROS: 13.02.2026 Views: 37 Downloads: 8 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:	Farm. vestn.
Publisher:	Slovensko farmacevtsko društvo
ISSN:	0014-8229
COBISS.SI-ID:	3105794

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License:	CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:	http://creativecommons.org/licenses/by-nc/4.0/
Description:	A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:	English
Title:	Drug-induced interstitial lung injury
Abstract:	Drug-induced interstitial lung injury is a rare but important cause of interstitial lung disease and accounts for 3–5% of cases. Over 400 drugs – including antirheumatics, antineoplastics, and antiarrhythmics – have been associated with this condition. The clinical presentation ranges from asymptomatic disease to life-threatening respiratory failure. Early stages are potentially reversible with medicine discontinuation and anti-inflammatory therapy, but delayed recognition can lead to irreversible and potentially progressive fibrosis. Risk factors include older age, smoking, previous interstitial lung disease, and chest radiotherapy. Diagnosis is complex and is based on the exclusion of other causes, in particular infection and pulmonary disease. Management is based on discontinuation of the suspect causative agent and in more severe cases, on the prolonged use of systemic glucocorticosteroids. Immune checkpoint inhibitors have emerged as agrowing cause of drug-induced interstitial lung injury, with potentially higher incidence rates than conventional drugs, especially in lung cancer.
Keywords:	adverse drug reactions, interstitial lung injury, medicines

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