| Title: | Hypopituitarism, diabetes insipidus, and syndrome of inappropriate antidiuretic hormone secretion after pituitary macroadenoma surgery with indocyanine green dye |
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| Authors: | ID Felbabić, Tomislav (Author)
ID Velnar, Tomaž (Author)
ID Kocjan, Tomaž (Author) |
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| Files: |  PDF - Presentation file, download (844,43 KB)
MD5: C284BABC0954BA0B93D6DF86AA1FCAB3
 URL - Source URL, visit https://www.mdpi.com/2075-4418/14/17/1863
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Pituitary adenomas are benign tumors comprising about 18% of all intracranial tumors, and they often require surgical intervention. Differentiating pituitary tissue from adenoma during surgery is crucial to minimize complications. We hypothesized that using ICG dye would reduce the hormonal complication rates. (2) Methods: A prospective randomized study (February 2019-October 2023) included 34 patients with non-functional macroadenomas of the pituitary gland randomly assigned to receive intraoperative ICG or be in the control group. All underwent endoscopic endonasal transsphenoidal surgery. Pituitary function was assessed preoperatively, immediately postoperatively, and 3-6 months postoperatively. Adenohypophysis function was evaluated with hormonal tests (Cosyntropin stimulation test, TSH, fT3, fT4, prolactin, IGF-1, FSH, LH, and testosterone in men) and neurohypophysis function with fluid balance, plasma and urine osmolality, and serum and urinary sodium. (3) Results: Of the 34 patients (23 men, 11 women; average age 60.9 years), 5.9% in the ICG group developed diabetes insipidus postoperatively, compared to 23.5% in the control group. Adenohypophysis function worsened in 52.9% of the ICG group and in 35.3% of the control group. (4) Conclusions: Our study did not confirm the benefits of using ICG in these surgeries. Further research with a larger sample is needed. |
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| Keywords: | ICG dye, adenohypophysis, endoscopic endonasal surgery, neurohypophysis, non-functioning macroadenomas |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. [1]-12 |
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| Numbering: | Vol. 14, iss. 17, [article no.] 1863 |
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| PID: | 20.500.12556/DiRROS-27529  |
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| UDC: | 61 |
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| ISSN on article: | 2075-4418 |
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| DOI: | 10.3390/diagnostics14171863 |
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| COBISS.SI-ID: | 224102915 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 27. 1. 2025;
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| Publication date in DiRROS: | 11.02.2026 |
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| Views: | 392 |
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| Downloads: | 72 |
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