| Title: | Patient survival after resection of skeletal metastases and endoprosthetic reconstruction : a nation-wide cohort study in a single oncological institution |
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| Authors: | ID Merčun, Aljaž (Author)
ID Martinčič, David (Author)
ID Mavčič, Blaž (Author) |
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| Files: |  PDF - Presentation file, download (477,90 KB)
MD5: ACC65E9652FC10247E4A931E3524F2C6
 URL - Source URL, visit https://reference-global.com/article/10.2478/raon-2025-0009
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: The aim of this nation-wide 2009-2021 cohort study was to analyze postoperative survival of patients with resected appendicular skeletal metastases and endoprosthetic reconstruction in comparison to sarcoma patients and non-oncological reconstructions. Patients and methods: A single institution nation-wide cohort of 144 consecutive patients with tumor endoprosthetic reconstructions (32 resected metastases, 73 resected sarcomas, 39 non-oncological) were stratified into histopathological groups according to the 2013-SPRING prediction model. Their survival was analyzed with the Kaplan-Meier method and Cox regression. Results: The observed patient survival rates after wide resection of fast/moderate/slow growing metastases were 25/55/88% at 2 years and 10/30/83% at 5 years, while in sarcomas the observed survival rates were 80% at 2 years and 69% at 5 years. Estimated mean postoperative survival after resection of skeletal metastases was significantly shorter in comparison to sarcomas (4.6 years vs. 9.1 years, log-rank p < 0.001). Predictors of worse patient survival included higher age, pathologic fracture or >1 metastasis, diagnostic group fast-growing metastases and higher preoperative C-reactive protein (CRP). Conclusions: Wide resection and endoprosthetic reconstruction offer a reliable solution in selected patients with skeletal metastases. Higher age, fast-growing metastases (from bladder cancer, colorectal, hepatocellular, lung cancer, malignant melanoma, unknown origin), pathologic fracture or >1 metastasis and elevated CRP predict shorter patient survival and may represent a relative contraindication in this regard. |
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| Keywords: | skeletal metastases, wide resection, endoprosthetic reconstruction, patient survival |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 450-456 |
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| Numbering: | Vol. 59, iss. 3 |
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| PID: | 20.500.12556/DiRROS-27227  |
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| UDC: | 617.3:616-006 |
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| ISSN on article: | 1581-3207 |
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| DOI: | 10.2478/raon-2025-0009 |
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| COBISS.SI-ID: | 266648579 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 29. 1. 2026;
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| Publication date in DiRROS: | 29.01.2026 |
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| Views: | 90 |
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| Downloads: | 47 |
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