| Title: | Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation |
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| Authors: | ID Vitez, Luka (Author)
ID Mihailović, Peter Marko (Author)
ID Božič Mijovski, Mojca (Author)
ID Jug, Borut (Author)
ID Bunc, Matjaž (Author) |
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| Files: |  PDF - Presentation file, download (780,88 KB)
MD5: 6EB29A27A7992D19B7C9D2C0B6DF9354
 URL - Source URL, visit https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1722293
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: The expanding role of transcatheter aortic valve implantation (TAVI) highlights the need to identify factors influencing long-term outcomes. Systemic inflammatory response syndrome (SIRS) is a frequent post-procedural event that may adversely affect prognosis. Measurement of inflammatory biomarkers may improve the understanding of underlying mechanisms and refine patient risk stratification.Methods: This single-center, prospective cohort study, enrolled 62 consecutive patients undergoing TAVI, who were followed for up to 5 years. Blood samples were collected before TAVI, at 24 h and 3–6 months post-procedure. Changes in biomarker levels, predictors of SIRS, and inflammatory predictors of long-term outcomes were analyzed.Results: SIRS developed in 45% of patients. Significant temporal changes were observed in hs-CRP, TNF-α, sST2/IL-33, IL-10, and IL-2 levels, irrespective of baseline or procedural characteristics. The development of SIRS was associated with a higher risk of all-cause mortality or unplanned hospitalization at 5 years (HR 3.07, 95% CI 1.57–6.00; p = 0.001). Baseline hs-CRP (HR 1.21, 95% CI 1.09-1.35; p < 0.001) and IFN-γ (HR 1.22; 95% CI 1.09–1.36; p < 0.001) levels were predictive of adverse outcomes. In multivariable Cox analysis, these associations remained, though findings should be interpreted cautiously given the limited sample size.Conclusions: SIRS is a common post-TAVI phenomenon and may be linked to long-term outcomes. Elevated pre-procedural hs-CRP and IFN-γ levels were associated with higher risk for adverse events, suggesting they may serve as exploratory biomarkers for risk stratification in this population. |
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| Keywords: | systemic inflammatory response syndrome, SIRS, transcatheter aortic valve implantation, high sensitivity CRP, hs-CRP, interferon gamma, IFN-γ, inflammatory biomarkers |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2026 |
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| Number of pages: | str. 1-11 |
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| Numbering: | Vol. 12, [article no.] 1722293 |
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| PID: | 20.500.12556/DiRROS-26988  |
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| UDC: | 616.1 |
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| ISSN on article: | 2297-055X |
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| DOI: | 10.3389/fcvm.2025.1722293 |
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| COBISS.SI-ID: | 266429443 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 28. 1. 2026;
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| Publication date in DiRROS: | 28.01.2026 |
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| Views: | 64 |
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| Downloads: | 30 |
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