| Title: | Acute human bocavirus 1 infection in children hospitalized for acute bronchiolitis : a 2-year prospective study |
|---|
| Authors: | ID Uršič, Tina (Author)
ID Lusa, Lara (Author)
ID Strle, Franc (Author)
ID Pokorn, Marko (Author)
ID Mrvič, Tatjana (Author)
ID Grosek, Štefan (Author)
ID Petrovec, Miroslav (Author)
ID Jevšnik Virant, Monika (Author) |
|---|
| Files: |  PDF - Presentation file, download (618,04 KB)
MD5: 6CF4CCE4AF2ADF3EF9D4B1DD42878DDC
 URL - Source URL, visit https://journals.lww.com/pidj/fulltext/2025/03000/acute_human_bocavirus_1_infection_in_children.2.aspx
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  UKC LJ - Ljubljana University Medical Centre
|
|---|
| Abstract: | Background: The objective of this prospective study was to assess the proportion and clinical consequences of human bocavirus 1 (HBoV1) replication in children hospitalized for acute bronchiolitis (AB) with HBoV1 DNA in the nasopharynx (NP). Methods: For this purpose, we detected HBoV1 DNA and mRNA (evidence of viral replication and viable virus) in NP in cases and healthy control children. This research allowed us to distinguish active HBoV1 infections from inactive ones. Results: HBoV1 DNA was detected in the NP of 37 of 307 patients with AB (12.1%) and 9 of 150 children in a healthy control group (6%) with a high codetection rate with other respiratory viruses in AB patients, 28 of 37 (75.7%). Only 9 of 37 HBoV1 DNA-positive NP swabs (24.3%) with high DNA load were also HBoV1 mRNA positive, moreover, HBoV1 DNA was also detected in the plasma of these patients. Conclusions: Based on the results of our study, we can conclude that children with AB acute HBoV1 infection has a high HBoV1 DNA load in NP samples together with detected HBoV1 mRNA and detected HBoV1 DNA in plasma. |
|---|
| Keywords: | human bocavirus 1, infection, children, acute bronchiolitis |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Year of publishing: | 2025 |
|---|
| Number of pages: | str. 195-199 |
|---|
| Numbering: | Vol. 44, iss. 3 |
|---|
| PID: | 20.500.12556/DiRROS-25399  |
|---|
| UDC: | 61 |
|---|
| ISSN on article: | 1532-0987 |
|---|
| DOI: | 10.1097/INF.0000000000004613 |
|---|
| COBISS.SI-ID: | 222346499 |
|---|
| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 1. 2025; |
|---|
| Publication date in DiRROS: | 19.01.2026 |
|---|
| Views: | 92 |
|---|
| Downloads: | 57 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
