| Title: | Induction chemotherapy and concurrent chemoradiotherapy for larynx preservation in laryngeal and hypopharyngeal cancer |
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| Authors: | ID Strojan, Primož (Author)
ID Plavc, Gaber (Author)
ID Šifrer, Robert (Author)
ID Jereb, Simona (Author)
ID Lanišnik, Boštjan (Author)
ID Kokalj, Marko (Author)
ID Grošelj, Aleš (Author)
ID Grašič-Kuhar, Cvetka (Author) |
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| Files: |  URL - Source URL, visit https://reference-global.com/article/10.2478/raon-2025-0055
URL - Source URL, visit https://doi.org/10.2478/raon-2025-0055
 PDF - Presentation file, download (883,77 KB)
MD5: BEA12588AF1F76842D5E5BB5A12A8BF7
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
 UKC MB - University Medical Centre Maribor
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| Abstract: | To test the hypothesis that clinical tumor response after a single cycle of induction chemotherapy (ICT) can reliably differentiate between chemo-/radiosensitive and resistant tumors in the larynx preservation setting. Patients and methods Treatment consisted of docetaxel/cisplatin/5-fluorouracil (TPF) ICT followed by concurrent chemoradiotherapy (cCRT) with weekly cisplatin. The response of the primary tumor was assessed by transnasal endoscopy after the first ICT cycle. Results 37/39 (95%) patients with laryngeal (46%) or hypopharyngeal (54%) carcinoma responded to one cycle of ICT, and two patients were referred for salvage surgery. Laryngectomy-free survival at 2 and 5 years was 87% and 75%, respectively. The corresponding rates for locoregional control (and also for disease-free survival) were 79% and 70% and for overall survival 92% and 82%. Conclusions Clinical assessment of tumor response to one cycle of TPF ICT serves as a valid and easy-to-use predictor of tumor sensitivity to platinum-based cCRT. |
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| Keywords: | induction chemotherapy, chemoradiotherapy, arynx preservation |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 21.07.2025 |
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| Article acceptance date: | 05.09.2025 |
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| Publication date: | 01.12.2025 |
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| Place of publishing: | Ljubljana |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 579-588 |
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| Numbering: | Vol. 59, no. 4 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-25286  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2025-0055 |
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| COBISS.SI-ID: | 262922755 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Gaber Plavc, Robert Sifrer, Simona Jereb, Bostjan Lanisnik, Marko Kokalj, Ales Groselj, Cvetka Grasic Kuhar;
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| Publication date in DiRROS: | 16.01.2026 |
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| Views: | 123 |
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| Downloads: | 101 |
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