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Title: Induction chemotherapy and concurrent chemoradiotherapy for larynx preservation in laryngeal and hypopharyngeal cancer Authors: ID Strojan, Primož (Author) ID Plavc, Gaber (Author) ID Šifrer, Robert (Author) ID Jereb, Simona (Author) ID Lanišnik, Boštjan (Author) ID Kokalj, Marko (Author) ID Grošelj, Aleš (Author) ID Grašič-Kuhar, Cvetka (Author) Files: URL - Source URL, visit https://reference-global.com/article/10.2478/raon-2025-0055   URL - Source URL, visit https://doi.org/10.2478/raon-2025-0055   URL - Source URL, visit https://reference-global.com/article/10.2478/raon-2025-0055   This document has even more files. Complete list of files is available below. Language: English Typology: 1.01 - Original Scientific Article Organization: OI - Institute of Oncology UKC MB - University Medical Centre Maribor DRO - Association of Radiology and Oncology UKC LJ - Ljubljana University Medical Centre Abstract: To test the hypothesis that clinical tumor response after a single cycle of induction chemotherapy (ICT) can reliably differentiate between chemo-/radiosensitive and resistant tumors in the larynx preservation setting. Patients and methods Treatment consisted of docetaxel/cisplatin/5-fluorouracil (TPF) ICT followed by concurrent chemoradiotherapy (cCRT) with weekly cisplatin. The response of the primary tumor was assessed by transnasal endoscopy after the first ICT cycle. Results 37/39 (95%) patients with laryngeal (46%) or hypopharyngeal (54%) carcinoma responded to one cycle of ICT, and two patients were referred for salvage surgery. Laryngectomy-free survival at 2 and 5 years was 87% and 75%, respectively. The corresponding rates for locoregional control (and also for disease-free survival) were 79% and 70% and for overall survival 92% and 82%. Conclusions Clinical assessment of tumor response to one cycle of TPF ICT serves as a valid and easy-to-use predictor of tumor sensitivity to platinum-based cCRT. Keywords: induction chemotherapy, chemoradiotherapy, arynx preservation Publication status: Published Publication version: Version of Record Submitted for review: 21.07.2025 Article acceptance date: 05.09.2025 Publication date: 01.12.2025 Place of publishing: Ljubljana Publisher: Association of Radiology and Oncology Year of publishing: 2025 Number of pages: str. 579-588, XI Numbering: Vol. 59, no. 4 Source: Ljubljana PID: 20.500.12556/DiRROS-25286  UDC: 616-006 ISSN on article: 1318-2099 DOI: 10.2478/raon-2025-0055  COBISS.SI-ID: 262922755  Copyright: by Authors Note: Soavtorji: Gaber Plavc, Robert Sifrer, Simona Jereb, Bostjan Lanisnik, Marko Kokalj, Ales Groselj, Cvetka Grasic Kuhar; Publication date in DiRROS: 16.01.2026 Views: 481 Downloads: 598 Metadata:    Cite this work Plain text BibTeX EndNote XML EndNote/Refer RIS ABNT ACM Ref AMA APA Chicago 17th Author-Date Harvard IEEE ISO 690 MLA Vancouver : Copy citation

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Record is a part of a journal

Title:	Radiology and oncology
Shortened title:	Radiol. oncol.
Publisher:	Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:	1318-2099
COBISS.SI-ID:	32649472

Document is financed by a project

Funder:	ARIS - Slovenian Research and Innovation Agency
Project number:	P3-0307-2019
Name:	Rak glave in vratu - analiza bioloških značilnosti in poskus izboljšanja zdravljenja

Licences

License:	CC BY 4.0, Creative Commons Attribution 4.0 International
Link:	http://creativecommons.org/licenses/by/4.0/
Description:	This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:	Slovenian
Title:	Indukcijska kemoterapija in sočasna kemoradioterapija za ohranitev grla pri raku grla in hipofaringealnem raku
Keywords:	indukcijska kemoterapija, kemoradioterapija, ohranitev grla

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