| Title: | Polymorphisms rs1800587 and rs1143634 of the interleukin-1α gene are associated with the progression of carotid atherosclerosis in Caucasians with type 2 diabetes mellitus |
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| Authors: | ID Pleskovič, Aleš (Author)
ID Nikolajević, Jovana (Author)
ID Mankoč Ramuš, Sara (Author)
ID Cilenšek, Ines (Author)
ID Šantl-Letonja, Marija (Author)
ID Makuc, Jana (Author)
ID Cokan Vujkovac, Andreja (Author)
ID Petrovič, Danijel (Author), et al. |
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| Files: |  PDF - Presentation file, download (585,09 KB)
MD5: 38FFD3889F031A0F7589C1DF441B4A9F
 URL - Source URL, visit https://www.hilarispublisher.com/abstract/polymorphisms-rs1800587-and-rs1143634-of-the-interleukin1alpha-gene-are-associated-with-the-progression-of-carotid-ather-26068.html
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Our study was designed to test the possible association between either polymorphisms T889C (rs1800587) or C3954T (rs1143634) of the interleukin-1 alpha (IL-1α) gene with subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Moreover, the effect of both polymorphisms on progression of carotid atherosclerosis in 3.8-year follow-up was studied. Patients and methods: 595 subjects with T2DM were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed with ultrasound at the time of recruitment and after 3.8-years. Genotyping of two polymorphisms (rs1800587, rs1143634) was performed with real-time PCR System. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of IL-1α rs1800587 and rs1143634 polymorphisms upon enrolment. Multiple linear regression analysis revealed the association of IL-1α rs1143634 on total plaque thickness progression in a 3.8 year follow up. Conclusions: An association between either the IL-1α rs1800587 or rs1143634 and total plaque thickness at the time of recruitment was reported. Additionally, we demonstrated the effect of the IL-1α rs1143634 on total plaque thickness progression in the 3.8-year follow-up in patients with T2DM. |
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| Keywords: | carotid atherosclerosis, genetic polymorphism, interleukin-1 α, cross-sectional study |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 1-5 |
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| Numbering: | Vol. 1, iss. 3, [article no.] 1000113 |
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| PID: | 20.500.12556/DiRROS-25147  |
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| UDC: | 61 |
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| ISSN on article: | 2475-3211 |
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| DOI: | 10.4172/2475-3211.1000113 |
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| COBISS.SI-ID: | 263106563 |
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| Copyright: | V članku navedeno: "This is an open-access article distributed under the terms of the Creative Commons Attribution License." Na spletni strani revije navedeno: "Creative Commons License CC BY-NC-ND 4.0" (https://www.hilarispublisher.com/policies.html. 12. 1. 2026). |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 29. 12. 2025;
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| Publication date in DiRROS: | 12.01.2026 |
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| Views: | 115 |
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| Downloads: | 62 |
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