| Title: | The male hormone reset : how GLP-1RAs, lifestyle and testosterone transform obesity-linked problems |
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| Authors: | ID Groti Antonič, Kristina (Author)
ID Zitzmann, Michael (Author) |
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| Files: |  PDF - Presentation file, download (1,10 MB)
MD5: F9A257B13DC204912B4CAB5008349539
 URL - Source URL, visit https://www.tandfonline.com/doi/full/10.1080/13685538.2025.2601423
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Introduction: Functional hypogonadism, a manifestation of testosterone deficiency in simultaneously present comorbidities, profoundly impairs quality of life in men with overweight and obesity - yet remains persistently under-recognized in clinical practice. Findings: Lifestyle modification constitutes first-line therapy, while pharmacological and surgical interventions increasingly complement it. Both promote substantial weight loss and may reverse obesity-related hypogonadism; bariatric surgery, in particular, elicits marked rises in circulating testosterone but entails risks of bone demineralization and uncertain long-term reproductive sequelae. Notwithstanding, testosterone deficiency itself represents a key driver of secondary osteoporosis, insulin resistance, anemia, fatigue, and depression as well as sexual symptoms. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have redefined obesity therapy through profound weight reduction and cardiometabolic benefit, yet concomitant losses of lean mass raise concern over sarcopenia and skeletal fragility. Conclusion: This focused review article aims to present a comprehensive update on the latest data concerning combining testosterone therapy with contemporary anti-obesity pharmacotherapy as a new standard of care for obese men with functional hypogonadism, uniting metabolic, vascular, sexual, cognitive, and skeletal benefits within a comprehensive strategy to fortify corporeal resilience and enhance quality of life. |
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| Keywords: | male hypogonadism, testosterone, GLP-1RAs, obesity, bones, osteoporosis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-21 |
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| Numbering: | Vol. 28, no. 1, [article no.] 2601423 |
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| PID: | 20.500.12556/DiRROS-24874  |
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| UDC: | 616.4 |
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| ISSN on article: | 1473-0790 |
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| DOI: | 10.1080/13685538.2025.2601423 |
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| COBISS.SI-ID: | 262655235 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 12. 2025;
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| Publication date in DiRROS: | 23.12.2025 |
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| Views: | 9 |
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| Downloads: | 8 |
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| Metadata: |    |
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