| Title: | Impact of incretin-based therapy on skeletal muscle health |
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| Authors: | ID Koceva, Andrijana (Author)
ID Janež, Andrej (Author)
ID Jensterle Sever, Mojca (Author) |
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| Files: |  PDF - Presentation file, download (816,82 KB)
MD5: 6DBA8C49948CAC48D74A32C495E6062C
 URL - Source URL, visit https://www.mdpi.com/1648-9144/61/9/1691
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Skeletal muscle is the largest insulin-sensitive tissue in the human body, playing a crucial role in glucose homeostasis, body mobility and overall metabolic health. In obesity and type 2 diabetes (T2D), skeletal muscle undergoes structural, functional, and metabolic alterations, including reduced muscle mass, impaired contractile function, increased myosteatosis, mitochondrial dysfunction, and chronic low-grade inflammation. Incretin-based therapies such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) or dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RAs are highly effective treatments for T2D and obesity, producing substantial weight loss. While clinical trials suggest proportional loss of fat and lean mass when using incretin-based therapies, emerging preclinical and translational data indicate potential muscle-specific beneficial effects such as attenuation of atrophy, improved myogenesis, enhanced mitochondrial function and reduced myosteatosis. This review comprehensively summarizes the current preclinical and clinical evidence on the impact of incretin-based therapies on skeletal muscle mass, composition, metabolism, and performance, focusing on mechanistic insights from animal models and translational findings from human studies. |
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| Keywords: | obesity, incretin-based treatment, liraglutide |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-16 |
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| Numbering: | Vol. 61, iss. 9, [article no.] 1691 |
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| PID: | 20.500.12556/DiRROS-24855  |
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| UDC: | 616.4 |
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| ISSN on article: | 1648-9144 |
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| DOI: | 10.3390/medicina61091691 |
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| COBISS.SI-ID: | 249529603 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 18. 9. 2025;
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| Publication date in DiRROS: | 22.12.2025 |
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| Views: | 17 |
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| Downloads: | 9 |
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