| Title: | Case report : agranulocytosis in a child following metamizole use – a diagnostic challenge |
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| Authors: | ID Pirnat, Aljaž (Author)
ID Prelog, Tomaž (Author)
ID Jazbec, Janez (Author)
ID Trampuš-Bakija, Alenka (Author) |
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| Files: |  PDF - Presentation file, download (276,34 KB)
MD5: CC232014B761DEE9724B0503E8BFB214
 URL - Source URL, visit https://www.ama.ba/index.php/ama/article/view/598
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| Language: | English |
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| Typology: | 1.03 - Other scientific articles |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Objective: This case report describes a young female who developed agranulocytosis with blast cells in peripheral blood following prolonged metamizole use after ankle surgery. Case Report: A 17-year-old female patient was admitted to the Department of Infectious Diseases due to high fever and sore throat. Initial diagnostics revealed agranulocytosis, followed by occurrence of blast cells and left shifted neutrophils in the peripheral blood, in subsequent days. Extensive further diagnostics were performed due to suspicion of leukaemia, which was excluded after flow cytometry and cytogenetic analysis of bone marrow aspirate. After all tests were completed, the patient disclosed that she had been using metamizole for four months following ankle surgery. Conclusion: In cases of agranulocytosis, involving a prolonged history of metamizole use accompanied by the presence of blast cells and granulocyte precursors in peripheral blood, we would recommend an initial diagnostic approach that includes a complete blood count with differential and flow cytometry of peripheral blood. Bone marrow aspiration may be postponed or deemed unnecessary if peripheral blood flow cytometry shows no aberrant populations and there are no other signs of leukaemia. |
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| Keywords: | metamizole, agranulocytosis, leukaemia, blast cell, flow cytometry |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 51-55 |
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| Numbering: | Vol. 54, no. 1 |
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| PID: | 20.500.12556/DiRROS-24725  |
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| UDC: | 616-053.2 |
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| ISSN on article: | 1840-2879 |
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| DOI: | 10.5644/ama2006-124.472 |
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| COBISS.SI-ID: | 257420035 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 17. 11. 2025;
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| Publication date in DiRROS: | 15.12.2025 |
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| Views: | 9 |
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| Downloads: | 5 |
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