| Title: | Erythema migrans in patients with post-traumatic splenectomy |
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| Authors: | ID Maraspin-Čarman, Vera (Author)
ID Ogrinc, Katarina (Author)
ID Bogovič, Petra (Author)
ID Rojko, Tereza (Author)
ID Ružić-Sabljić, Eva (Author)
ID Wormser, Gary P. (Author)
ID Strle, Franc (Author) |
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| Files: |  PDF - Presentation file, download (514,76 KB)
MD5: 9B9F07506D95E5223A207E535BE7C0BD
 URL - Source URL, visit https://www.mdpi.com/2076-2607/12/7/1465
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Information on asplenic Lyme borreliosis (LB) patients with erythema migrans (EM) is lacking. We compared the course and outcome of 26 EM episodes in 24 post-trauma splenectomized patients (median age 51 years) diagnosed at a single clinical center in Slovenia during 1994–2023 with those of 52 age- and sex-matched patients with EM but with no history of splenectomy. All patients were followed for one year. A comparison of pre-treatment characteristics revealed that EM in splenectomized patients was of shorter duration before diagnosis (4 vs. 8 days, p = 0.034) with a smaller EM diameter (10.5 vs. 14 cm, p = 0.046), and more frequently fulfilled criteria for disseminated LB (3/26, 11.5% vs. 0%, p = 0.034). Treatment failure occurred in 5/26 (19.2%) EM episodes in splenectomized patients versus 0/52 in non-splenectomized patients (p = 0.003). The five treatment failure cases were retreated with antibiotic regimens used to treat EM and had complete resolution of all symptoms/signs. In conclusion, our study showed that splenectomized adult patients with EM differ somewhat in presentation and more often have treatment failure compared with non-splenectomized patients with EM. |
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| Keywords: | erythema migrans, Lyme borreliosis, Lyme disease |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Vol. 12, iss. 7, [article no.] 1465 |
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| PID: | 20.500.12556/DiRROS-24579  |
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| UDC: | 616.9:579 |
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| ISSN on article: | 2076-2607 |
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| DOI: | 10.3390/microorganisms12071465 |
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| COBISS.SI-ID: | 217710595 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 4. 12. 2024;
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| Publication date in DiRROS: | 08.12.2025 |
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| Views: | 74 |
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| Downloads: | 41 |
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